Detailed information of TA system TA183101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1223337..1223860
• Replicon: chromosome
• Accession: NZ_CP065635
• Organism: Staphylococcus pseudintermedius strain FDAARGOS_930

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6G87_RS05830
• Protein ID: WP_015729746.1
• Coordinates: 1223337..1223603 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2P5PI69
• Locus tag: I6G87_RS05835
• Protein ID: WP_015729747.1
• Coordinates: 1223603..1223860 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G87_RS05820	1221368..1222861	+	1494	WP_014612817.1	malate dehydrogenase (quinone)	-
I6G87_RS05825	1222875..1222976	+	102	WP_019169745.1	DUF2648 domain-containing protein	-
I6G87_RS05830	1223337..1223603	-	267	WP_015729746.1	Txe/YoeB family addiction module toxin	Toxin
I6G87_RS05835	1223603..1223860	-	258	WP_015729747.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6G87_RS05840	1224054..1225958	-	1905	WP_015729748.1	triacylglycerol lipase	-
I6G87_RS05845	1226218..1226712	+	495	WP_015729749.1	membrane protein	-
I6G87_RS05850	1227024..1227812	-	789	WP_063284837.1	arylamine N-acetyltransferase	-
I6G87_RS05855	1228340..1228522	+	183	WP_096536006.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10541.08 Da
• Isoelectric Point: 10.1602

>T183101 WP_015729746.1 NZ_CP065635:c1223603-1223337 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKVNPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FSAWSYYE

Nucleotide

• Length: 267 bp

>T183101 NZ_CP086663:c40728-40348 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGCATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACTTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGTGCTGCGACTGG
CGGGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTTCGGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9836.85 Da
• Isoelectric Point: 4.1100

>AT183101 WP_015729747.1 NZ_CP065635:c1223860-1223603 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDGIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT183101 NZ_CP086663:c40949-40728 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGGGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A2P5PI69