Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 427164..427734 Replicon chromosome
Accession NZ_CP065630
Organism Brevibacterium casei strain FDAARGOS_936

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G93_RS01925 Protein ID WP_101624910.1
Coordinates 427164..427445 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G93_RS01930 Protein ID WP_095375736.1
Coordinates 427432..427734 (+) Length 101 a.a.

Genomic Context

I6G93_RS01925I6G93_RS01930I6G93_RS01935I6G93_RS01940I6G93_RS01945I6G93_RS01960I6G93_RS01965I6G93_RS01905I6G93_RS01910I6G93_RS01915I6G93_RS01920I6G93_RS01950I6G93_RS01955
Location: 427164..427445 (282 bp)
Type: Toxin
Protein ID: WP_101624910.1
Location: 427432..427734 (303 bp)
Type: Antitoxin
Protein ID: WP_095375736.1
Location: 427738..428292 (555 bp)
Type: Others
Protein ID: WP_101624911.1
Location: 428356..428862 (507 bp)
Type: Others
Protein ID: WP_101624912.1
Location: 429018..429395 (378 bp)
Type: Others
Protein ID: WP_101624913.1
Location: 431145..431354 (210 bp)
Type: Others
Protein ID: WP_101624915.1
Location: 431463..432698 (1236 bp)
Type: Others
Protein ID: WP_197907844.1
Location: 423271..423780 (510 bp)
Type: Others
Protein ID: WP_101624907.1
Location: 423828..424817 (990 bp)
Type: Others
Protein ID: WP_146001453.1
Location: 424878..425024 (147 bp)
Type: Others
Protein ID: WP_180960668.1
Location: 425521..427065 (1545 bp)
Type: Others
Protein ID: WP_101624909.1
Location: 429456..429725 (270 bp)
Type: Others
Protein ID: WP_095375740.1
Location: 429885..431030 (1146 bp)
Type: Others
Protein ID: WP_101624914.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G93_RS01905423271..423780-510WP_101624907.1hypothetical protein-
I6G93_RS01910423828..424817-990WP_146001453.1hypothetical protein-
I6G93_RS01915424878..425024-147WP_180960668.1hypothetical protein-
I6G93_RS01920425521..427065-1545WP_101624909.1recombinase family protein-
I6G93_RS01925427164..427445+282WP_101624910.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6G93_RS01930427432..427734+303WP_095375736.1HigA family addiction module antidote proteinAntitoxin
I6G93_RS01935427738..428292+555WP_101624911.1GNAT family N-acetyltransferase-
I6G93_RS01940428356..428862+507WP_101624912.1hypothetical protein-
I6G93_RS01945429018..429395+378WP_101624913.1hypothetical protein-
I6G93_RS01950429456..429725-270WP_095375740.1DUF3263 domain-containing protein-
I6G93_RS01955429885..431030-1146WP_101624914.1glycerol dehydrogenase-
I6G93_RS01960431145..431354+210WP_101624915.1hypothetical protein-
I6G93_RS01965431463..432698+1236WP_197907844.1low temperature requirement protein A-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--411362..42886217500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10872.34 Da        Isoelectric Point: 9.1995

>T183097 WP_101624910.1 NZ_CP065630:427164-427445 [Brevibacterium casei]
VIRSFGSKETERLWRRERVRSIDPRIHRVALRKLRQVGSAEVLEDLSVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T183097 NZ_CP086662:3652012-3652389 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.61 Da        Isoelectric Point: 5.1100

>AT183097 WP_095375736.1 NZ_CP065630:427432-427734 [Brevibacterium casei]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSPEFWINLQSHYEL
DRAEDAAGEQIAAITPLRVA

Download         Length: 303 bp

>AT183097 NZ_CP086662:3651554-3651922 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References