Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 427164..427734 Replicon chromosome
Accession NZ_CP065630
Organism Brevibacterium casei strain FDAARGOS_936

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G93_RS01925 Protein ID WP_101624910.1
Coordinates 427164..427445 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G93_RS01930 Protein ID WP_095375736.1
Coordinates 427432..427734 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G93_RS01905 423271..423780 - 510 WP_101624907.1 hypothetical protein -
I6G93_RS01910 423828..424817 - 990 WP_146001453.1 hypothetical protein -
I6G93_RS01915 424878..425024 - 147 WP_180960668.1 hypothetical protein -
I6G93_RS01920 425521..427065 - 1545 WP_101624909.1 recombinase family protein -
I6G93_RS01925 427164..427445 + 282 WP_101624910.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G93_RS01930 427432..427734 + 303 WP_095375736.1 HigA family addiction module antidote protein Antitoxin
I6G93_RS01935 427738..428292 + 555 WP_101624911.1 GNAT family N-acetyltransferase -
I6G93_RS01940 428356..428862 + 507 WP_101624912.1 hypothetical protein -
I6G93_RS01945 429018..429395 + 378 WP_101624913.1 hypothetical protein -
I6G93_RS01950 429456..429725 - 270 WP_095375740.1 DUF3263 domain-containing protein -
I6G93_RS01955 429885..431030 - 1146 WP_101624914.1 glycerol dehydrogenase -
I6G93_RS01960 431145..431354 + 210 WP_101624915.1 hypothetical protein -
I6G93_RS01965 431463..432698 + 1236 WP_197907844.1 low temperature requirement protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 411362..428862 17500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10872.34 Da        Isoelectric Point: 9.1995

>T183097 WP_101624910.1 NZ_CP065630:427164-427445 [Brevibacterium casei]
VIRSFGSKETERLWRRERVRSIDPRIHRVALRKLRQVGSAEVLEDLSVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T183097 NZ_CP086662:3652012-3652389 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.61 Da        Isoelectric Point: 5.1100

>AT183097 WP_095375736.1 NZ_CP065630:427432-427734 [Brevibacterium casei]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSPEFWINLQSHYEL
DRAEDAAGEQIAAITPLRVA

Download         Length: 303 bp

>AT183097 NZ_CP086662:3651554-3651922 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References