Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 911404..911974 Replicon chromosome
Accession NZ_CP065629
Organism Brevibacterium casei strain FDAARGOS_937

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6G94_RS04280 Protein ID WP_101624910.1
Coordinates 911404..911685 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6G94_RS04285 Protein ID WP_095375736.1
Coordinates 911672..911974 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G94_RS04260 907511..908020 - 510 WP_101624907.1 hypothetical protein -
I6G94_RS04265 908068..909057 - 990 WP_146001453.1 hypothetical protein -
I6G94_RS04270 909118..909264 - 147 WP_180960668.1 hypothetical protein -
I6G94_RS04275 909761..911305 - 1545 WP_101624909.1 recombinase family protein -
I6G94_RS04280 911404..911685 + 282 WP_101624910.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G94_RS04285 911672..911974 + 303 WP_095375736.1 HigA family addiction module antidote protein Antitoxin
I6G94_RS04290 911978..912532 + 555 WP_101624911.1 GNAT family N-acetyltransferase -
I6G94_RS04295 912596..913102 + 507 WP_101624912.1 hypothetical protein -
I6G94_RS04300 913258..913635 + 378 WP_101624913.1 hypothetical protein -
I6G94_RS04305 913696..913965 - 270 WP_095375740.1 DUF3263 domain-containing protein -
I6G94_RS04310 914125..915270 - 1146 WP_101624914.1 glycerol dehydrogenase -
I6G94_RS04315 915385..915594 + 210 WP_101624915.1 hypothetical protein -
I6G94_RS04320 915703..916938 + 1236 WP_197907844.1 low temperature requirement protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 881945..913102 31157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-97)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10872.34 Da        Isoelectric Point: 9.1995

>T183096 WP_101624910.1 NZ_CP065629:911404-911685 [Brevibacterium casei]
VIRSFGSKETERLWRRERVRSIDPRIHRVALRKLRQVGSAEVLEDLSVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T183096 NZ_CP086662:3578630-3578980 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.61 Da        Isoelectric Point: 5.1100

>AT183096 WP_095375736.1 NZ_CP065629:911672-911974 [Brevibacterium casei]
MTTTDKIEPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSPEFWINLQSHYEL
DRAEDAAGEQIAAITPLRVA

Download         Length: 303 bp

>AT183096 NZ_CP086662:3578385-3578636 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References