Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2517877..2518551 Replicon chromosome
Accession NZ_CP065627
Organism Delftia acidovorans strain FDAARGOS_939

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag I6G96_RS11360 Protein ID WP_043789322.1
Coordinates 2518270..2518551 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag I6G96_RS11355 Protein ID WP_012203141.1
Coordinates 2517877..2518188 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G96_RS11345 2513366..2514388 + 1023 WP_047219648.1 type I-F CRISPR-associated endonuclease Cas1 -
I6G96_RS11350 2514385..2517873 + 3489 WP_197944906.1 type I-F CRISPR-associated helicase Cas3 -
I6G96_RS11355 2517877..2518188 - 312 WP_012203141.1 HigA family addiction module antidote protein Antitoxin
I6G96_RS11360 2518270..2518551 - 282 WP_043789322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G96_RS11365 2518717..2520066 + 1350 WP_197944907.1 type I-F CRISPR-associated protein Csy1 -
I6G96_RS11370 2520063..2521145 + 1083 WP_197944908.1 type I-F CRISPR-associated protein Csy2 -
I6G96_RS11375 2521200..2522228 + 1029 WP_197944909.1 type I-F CRISPR-associated protein Csy3 -
I6G96_RS11380 2522234..2522800 + 567 WP_141830492.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-98)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10721.30 Da        Isoelectric Point: 8.5442

>T183093 WP_043789322.1 NZ_CP065627:c2518551-2518270 [Delftia acidovorans]
MAITSFKCPETQRLFTSGKTRRFANIQSVAERKLAQLDAAVTLEFLRSPPGNRLEMLVGDRQGQHSIRINDQWRLCFVWT
EKGVVDVEIVDYH

Download         Length: 282 bp

>T183093 NZ_CP086662:c2802795-2802688 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11615.32 Da        Isoelectric Point: 8.6927

>AT183093 WP_012203141.1 NZ_CP065627:c2518188-2517877 [Delftia acidovorans]
MLKNGMRPIHPGEVLREDYLKPMDMSANALARHLHVPASRVNDIVLERRGITADTALRLSRFFGGDAQSWLNLQTAYDLR
TAELNAELQASVRQVHPMQLHTA

Download         Length: 312 bp

>AT183093 NZ_CP086662:2802843-2802909 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References