Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3296322..3296863 Replicon chromosome
Accession NZ_CP065624
Organism Escherichia coli strain FDAARGOS_941

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag I6G98_RS17250 Protein ID WP_000615979.1
Coordinates 3296322..3296600 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag I6G98_RS17255 Protein ID WP_000729704.1
Coordinates 3296603..3296863 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G98_RS17235 3293904..3294482 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
I6G98_RS17240 3294688..3295455 + 768 WP_001365365.1 class II glutamine amidotransferase -
I6G98_RS17245 3295426..3296166 - 741 WP_001225679.1 murein L,D-transpeptidase -
I6G98_RS17250 3296322..3296600 - 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
I6G98_RS17255 3296603..3296863 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
I6G98_RS17260 3297049..3297822 + 774 WP_000543899.1 C40 family peptidase -
I6G98_RS17265 3297879..3298235 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
I6G98_RS17270 3298228..3298506 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
I6G98_RS17275 3298611..3300704 - 2094 WP_032358908.1 flagellar biosynthesis protein FlhA -
I6G98_RS17280 3300688..3301827 - 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T183073 WP_000615979.1 NZ_CP065624:c3296600-3296322 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T183073 NZ_CP086659:c275151-274882 [Staphylococcus capitis]
ATGAGTAAGTTTAGTGTAACTTTTACAGCTCAAGCATTTAAAGATTATCAATATTGGCAACAACACAATCAAAATTATTT
TAAAAAAGTGAATGCTTTACTTAAAAGTATTGCAAGAGATGGTTGTGTCGATGGTATTGGAAAACCAGAAGCATTAAAAG
GAAACTACGAAGGCTATTTCAGTAGAAGAGTTTCAATAGAACACCGATTAATATACAAAATTAAGGATGATTCAATATTC
GTAGTGTCTTGCAGATTTCATTATCAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT183073 WP_000729704.1 NZ_CP065624:c3296863-3296603 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT183073 NZ_CP086659:c275401-275144 [Staphylococcus capitis]
ATGCCTTCAGTTAATTATTCAAACGCTAGACAGAATTTCAAAGAACTTATTACTAAAGTGAACGAGGATAGTGTGGCTTA
CACTATTACGACAAAGGAAAATGAAAATGCAGTGATTTTAGCTGAAAAGGATTATAATGCGATGTTGGAAACGATGTACC
TTCAATCCAATCTCGCTAATGTGTCTCACTTAAATCAATCAATTATGGAATTGAATCATAACCAAACAATTACAATAGAG
ATTGATGATAATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References