Detailed information of TA system TA183071

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2992874..2993132
• Replicon: chromosome
• Accession: NZ_CP065624
• Organism: Escherichia coli strain FDAARGOS_941

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6G98_RS15765
• Protein ID: WP_000809168.1
• Coordinates: 2992874..2993026 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2993075..2993132 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G98_RS15750	2988331..2990247	+	1917	WP_032359190.1	molecular chaperone DnaK	-
I6G98_RS15755	2990336..2991466	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6G98_RS15760	2991577..2992767	-	1191	WP_001111632.1	IS4-like element ISEc60 family transposase	-
I6G98_RS15765	2992874..2993026	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	2993075..2993132	+	58	-	-	Antitoxin
I6G98_RS15770	2993612..2994778	+	1167	WP_000681368.1	Na+/H+ antiporter NhaA	-
I6G98_RS15775	2994844..2995743	+	900	WP_001300855.1	transcriptional activator NhaR	-
I6G98_RS15780	2995781..2996488	-	708	Protein_2915	fimbrial family protein	-
I6G98_RS15785	2996529..2997226	+	698	Protein_2916	IS1 family transposase	-
I6G98_RS15790	2997557..2997820	-	264	WP_001274021.1	30S ribosomal protein S20	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2991577..2997226	5649

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T183071 WP_000809168.1 NZ_CP065624:c2993026-2992874 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T183071 NZ_CP086654:741099-741452 [Staphylococcus ratti]
ATGAAGCGTGGAGACGTTTATTTAGCAGATTTATCACCAGTCCAAGGGTCAGAGCAAGGGGGAGTCAGACCTGTCGTAAT
CATTCAAAATGATACTGGGAACAAATACAGTCCAACTGTTATTGTAGCGGCGATTACTGGACGTATTAACAAAGCAAAAA
TTCCAACACACGTTGAAATTGAAAAAAATAAATACAAACTCGACAAAGATTCAGTCATCTTGTTAGAACAAATAAGAACA
GTCGATAAAAAGAGGCTTAAAGAAAAGCTCACTTATCTTTCAGATGAAAAAATGAAAGAAGTCAACGCTGCACTTGGAAT
TAGTCTAGGATTGCACATGAATCAACACAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT183071 NZ_CP065624:2993075-2993132 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin