Detailed information of TA system TA182941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 478252..478818
• Replicon: chromosome
• Accession: NZ_CP065604
• Organism: Aggregatibacter actinomycetemcomitans strain FDAARGOS_948

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JU35
• Locus tag: I6H05_RS02235
• Protein ID: WP_005543444.1
• Coordinates: 478252..478530 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: I6H05_RS02240
• Protein ID: WP_005543446.1
• Coordinates: 478546..478818 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H05_RS02210	473808..474362	+	555	WP_005543432.1	HAD family hydrolase	-
I6H05_RS02215	474530..476077	+	1548	WP_025298400.1	anthranilate synthase component 1	-
I6H05_RS02220	476088..476678	+	591	WP_005543437.1	aminodeoxychorismate/anthranilate synthase component II	-
I6H05_RS02225	476752..477144	+	393	WP_005543439.1	tautomerase family protein	-
I6H05_RS02230	477156..478157	+	1002	WP_005567382.1	anthranilate phosphoribosyltransferase	-
I6H05_RS02235	478252..478530	+	279	WP_005543444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6H05_RS02240	478546..478818	+	273	WP_005543446.1	HigA family addiction module antidote protein	Antitoxin
I6H05_RS02245	478827..480253	+	1427	Protein_436	bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF	-
I6H05_RS02250	480708..480983	+	276	WP_005561117.1	hydrogenase maturation factor HybG	-
I6H05_RS02255	481104..481481	-	378	WP_005543455.1	hypothetical protein	-
I6H05_RS02260	481456..481647	-	192	WP_005553960.1	hypothetical protein	-
I6H05_RS02265	482008..482274	+	267	WP_005543457.1	oxaloacetate decarboxylase subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-79)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10490.95 Da
• Isoelectric Point: 9.5983

>T182941 WP_005543444.1 NZ_CP065604:478252-478530 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T182941 NZ_CP086622:c4512851-4512564 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10138.74 Da
• Isoelectric Point: 7.3169

>AT182941 WP_005543446.1 NZ_CP065604:478546-478818 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Nucleotide

• Length: 273 bp

>AT182941 NZ_CP086622:c4512577-4512275 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: X2JU35