Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 37025..37544 Replicon 1 plasmid p1_44kb
Accession NZ_CP065550
Organism Enterococcus faecium strain Dallas

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag I7089_RS15410 Protein ID WP_000588503.1
Coordinates 37287..37544 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag I7089_RS15405 Protein ID WP_000388479.1
Coordinates 37025..37294 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7089_RS15380 32297..33774 + 1478 Protein_35 type I restriction-modification system subunit M -
I7089_RS15385 33797..34477 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
I7089_RS15390 35012..35692 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
I7089_RS15395 35768..36334 + 567 Protein_38 hypothetical protein -
I7089_RS15400 36715..36894 + 180 WP_001120991.1 hypothetical protein -
I7089_RS15405 37025..37294 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I7089_RS15410 37287..37544 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
I7089_RS15415 38003..39007 + 1005 WP_000455809.1 hypothetical protein -
I7089_RS15420 39172..39786 - 615 WP_001261742.1 recombinase family protein -
I7089_RS15425 40236..41561 + 1326 WP_000969590.1 Y-family DNA polymerase -
I7089_RS15430 41554..41904 + 351 WP_000568378.1 hypothetical protein -
I7089_RS15435 41901..42080 + 180 WP_001021554.1 hypothetical protein -
I7089_RS15440 42216..42506 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..44323 44323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T182901 WP_000588503.1 NZ_CP065550:37287-37544 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T182901 NZ_CP086620:c957259-956885 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT182901 WP_000388479.1 NZ_CP065550:37025-37294 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT182901 NZ_CP086620:c957680-957306 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References