Detailed information of TA system TA182898

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 38702..38907
• Replicon: 1 plasmid p1_55kb
• Accession: NZ_CP065548
• Organism: Enterococcus faecium strain Dallas

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E3USR6
• Locus tag: I7089_RS14045
• Protein ID: WP_002295624.1
• Coordinates: 38785..38907 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	38702..38803 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7089_RS14015	33907..36111	+	2205	WP_025481008.1	type IA DNA topoisomerase	-
I7089_RS14020	36127..36276	+	150	WP_002295632.1	hypothetical protein	-
I7089_RS14025	36350..36943	+	594	WP_002287520.1	transcriptional regulator	-
I7089_RS14030	36959..37858	+	900	WP_002305191.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
I7089_RS14035	37861..38346	+	486	WP_002295626.1	single-stranded DNA-binding protein	-
I7089_RS14040	38368..38625	+	258	WP_002305195.1	hypothetical protein	-
-	38702..38803	+	102	NuclAT_0	-	Antitoxin
I7089_RS14045	38785..38907	-	123	WP_002295624.1	putative holin-like toxin	Toxin
I7089_RS14050	39061..39321	+	261	WP_049055261.1	hypothetical protein	-
I7089_RS14055	39764..39964	+	201	WP_002305199.1	hypothetical protein	-
I7089_RS14060	39969..40406	+	438	WP_002287515.1	hypothetical protein	-
I7089_RS14065	40399..41106	+	708	WP_002305202.1	hypothetical protein	-
I7089_RS14070	41487..41666	+	180	WP_002305204.1	hypothetical protein	-
I7089_RS14075	42272..42877	+	606	WP_002300095.1	Fic family protein	-
I7089_RS14080	42893..43468	+	576	WP_002300096.1	recombinase family protein	-
I7089_RS14085	43628..43831	+	204	WP_002300097.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55498	55498

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4431.42 Da
• Isoelectric Point: 10.3686

>T182898 WP_002295624.1 NZ_CP065548:c38907-38785 [Enterococcus faecium]
MKGVSLLSAYETIQTILGFGMFTIALISLIVNMLKNDKKK

Nucleotide

• Length: 123 bp

>T182898 NZ_CP086620:263303-263410 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 102 bp

>AT182898 NZ_CP065548:38702-38803 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Structures

Toxin

• AlphaFold DB: E3USR6

Antitoxin