Detailed information of TA system TA182891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1427907..1428397
• Replicon: chromosome
• Accession: NZ_CP065535
• Organism: Enterococcus durans strain KCTC 13289

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I4Q39_RS06695
• Protein ID: WP_025481334.1
• Coordinates: 1428143..1428397 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2A7SML8
• Locus tag: I4Q39_RS06690
• Protein ID: WP_016176676.1
• Coordinates: 1427907..1428158 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I4Q39_RS06675	1422973..1424160	+	1188	WP_060789696.1	LCP family protein	-
I4Q39_RS06680	1424480..1426666	+	2187	WP_060789695.1	type IA DNA topoisomerase	-
I4Q39_RS06685	1426787..1427068	+	282	WP_171024578.1	hypothetical protein	-
I4Q39_RS06690	1427907..1428158	+	252	WP_016176676.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I4Q39_RS06695	1428143..1428397	+	255	WP_025481334.1	Txe/YoeB family addiction module toxin	Toxin
I4Q39_RS06700	1428802..1429149	-	348	WP_005876025.1	bacteriocin immunity protein	-
I4Q39_RS06705	1429657..1431873	+	2217	WP_060789694.1	helix-turn-helix domain-containing protein	-
I4Q39_RS06710	1431968..1432183	-	216	Protein_1312	hypothetical protein	-
I4Q39_RS06715	1432453..1433073	-	621	Protein_1313	DUF624 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-76)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10104.87 Da
• Isoelectric Point: 10.1401

>T182891 WP_025481334.1 NZ_CP065535:1428143-1428397 [Enterococcus durans]
MGYNIKIKKNARKDLPKLKGANLNDKFDELITVIRENPYQNPPPYEKLMWLLYYSRRINIKYRLVYSVEDQNLYGLIMNT
GFKM

Nucleotide

• Length: 255 bp

>T182891 NZ_CP086618:c5007557-5007246 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTCACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9461.42 Da
• Isoelectric Point: 3.9947

>AT182891 WP_016176676.1 NZ_CP065535:1427907-1428158 [Enterococcus durans]
MEVISPTNARKNLYEIIKHVVSDSQPIEISSTKDGESVVMISKSDWNSLQETIYLQNAGVLDQIHHFENEESEDLGEIDW
DTI

Nucleotide

• Length: 252 bp

>AT182891 NZ_CP086618:c5007245-5006955 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A2A7SML8