Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1900480..1901132 Replicon plasmid megaplasmid
Accession NZ_CP065532
Organism Ralstonia solanacearum strain 362200

Toxin (Protein)


Gene name higB Uniprot ID A0A0S4U5H4
Locus tag IMF25_RS24740 Protein ID WP_028861315.1
Coordinates 1900480..1900824 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IMF25_RS24745 Protein ID WP_020425351.1
Coordinates 1900821..1901132 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMF25_RS24725 1896175..1897338 - 1164 WP_011003438.1 2-methylcitrate synthase -
IMF25_RS24730 1897390..1898286 - 897 WP_071092368.1 methylisocitrate lyase -
IMF25_RS24735 1898480..1900429 + 1950 WP_111375053.1 propionate catabolism operon regulatory protein PrpR -
IMF25_RS24740 1900480..1900824 + 345 WP_028861315.1 hypothetical protein Toxin
IMF25_RS24745 1900821..1901132 + 312 WP_020425351.1 transcriptional regulator Antitoxin
IMF25_RS24750 1901272..1902081 - 810 WP_043885575.1 DUF2242 domain-containing protein -
IMF25_RS24755 1902740..1903399 - 660 WP_127592217.1 hypothetical protein -
IMF25_RS24760 1903727..1905565 + 1839 WP_080624796.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - cyaB / flgC / flgG / fliM / fliG / fliI / acrB / htpB / adeG / cheY / cheB / cheW / motA 1..2034020 2034020


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13276.03 Da        Isoelectric Point: 9.3395

>T182882 WP_028861315.1 NZ_CP065532:1900480-1900824 [Ralstonia solanacearum]
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIYYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

>T182882 NZ_CP086618:3019583-3019690 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11619.65 Da        Isoelectric Point: 10.7132

>AT182882 WP_020425351.1 NZ_CP065532:1900821-1901132 [Ralstonia solanacearum]
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT182882 NZ_CP086618:c3019533-3019470 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4U5H4

Antitoxin

Source ID Structure

References