Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2552915..2553099 Replicon chromosome
Accession NZ_CP065515
Organism Staphylococcus aureus strain GDY8P96A

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag IQE12_RS12720 Protein ID WP_000482647.1
Coordinates 2552992..2553099 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2552915..2552975 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE12_RS12705 2548389..2548556 - 168 WP_001790576.1 hypothetical protein -
IQE12_RS12710 2548787..2550520 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
IQE12_RS12715 2550545..2552308 - 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
- 2552915..2552975 + 61 - - Antitoxin
IQE12_RS12720 2552992..2553099 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
IQE12_RS12725 2553233..2553619 - 387 WP_000779360.1 flippase GtxA -
IQE12_RS12730 2553877..2555019 + 1143 WP_001176871.1 glycerate kinase -
IQE12_RS12735 2555079..2555738 + 660 WP_000831301.1 membrane protein -
IQE12_RS12740 2555920..2557131 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
IQE12_RS12745 2557254..2557727 - 474 WP_000456497.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T182865 WP_000482647.1 NZ_CP065515:c2553099-2552992 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T182865 NZ_CP086617:63753-64028 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTATGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 61 bp

>AT182865 NZ_CP065515:2552915-2552975 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References