Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2527434..2527951 Replicon chromosome
Accession NZ_CP065515
Organism Staphylococcus aureus strain GDY8P96A

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IQE12_RS12585 Protein ID WP_000113262.1
Coordinates 2527434..2527700 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IQE12_RS12590 Protein ID WP_000584499.1
Coordinates 2527700..2527951 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE12_RS12560 2522859..2523386 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
IQE12_RS12565 2523630..2524454 - 825 WP_000572040.1 formate/nitrite transporter family protein -
IQE12_RS12570 2524671..2524853 - 183 WP_000230294.1 hypothetical protein -
IQE12_RS12575 2524937..2525404 - 468 WP_000153344.1 SRPBCC domain-containing protein -
IQE12_RS12580 2525590..2527140 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IQE12_RS12585 2527434..2527700 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IQE12_RS12590 2527700..2527951 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQE12_RS12595 2528116..2528217 - 102 Protein_2436 hypothetical protein -
IQE12_RS12600 2528224..2528823 - 600 WP_000162810.1 DsbA family protein -
IQE12_RS12605 2528842..2529204 - 363 WP_000819843.1 DUF4467 domain-containing protein -
IQE12_RS12610 2529460..2530710 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IQE12_RS12615 2530807..2531538 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
IQE12_RS12620 2531535..2532254 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T182864 WP_000113262.1 NZ_CP065515:c2527700-2527434 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T182864 NZ_CP086616:c4964348-4964037 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTCACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT182864 WP_000584499.1 NZ_CP065515:c2527951-2527700 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT182864 NZ_CP086616:c4964036-4963746 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References