Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2274444..2274641 Replicon chromosome
Accession NZ_CP065515
Organism Staphylococcus aureus strain GDY8P96A

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag IQE12_RS11280 Protein ID WP_001802298.1
Coordinates 2274537..2274641 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF
Locus tag -
Coordinates 2274444..2274482 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE12_RS11260 2270628..2271293 - 666 WP_001024105.1 SDR family oxidoreductase -
IQE12_RS11265 2271445..2271765 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
IQE12_RS11270 2271767..2272747 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
IQE12_RS11275 2273013..2274104 + 1092 WP_000495683.1 hypothetical protein -
- 2274444..2274482 + 39 - - Antitoxin
IQE12_RS11280 2274537..2274641 - 105 WP_001802298.1 hypothetical protein Toxin
IQE12_RS11285 2275321..2275479 + 159 WP_001792784.1 hypothetical protein -
IQE12_RS11290 2276138..2276995 - 858 WP_000370917.1 Cof-type HAD-IIB family hydrolase -
IQE12_RS11295 2277063..2277845 - 783 WP_000908178.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T182863 WP_001802298.1 NZ_CP065515:c2274641-2274537 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T182863 NZ_CP086616:c4668226-4668053 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 39 bp

>AT182863 NZ_CP065515:2274444-2274482 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References