Detailed information of TA system TA182857

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1973988..1974170
• Replicon: chromosome
• Accession: NZ_CP065515
• Organism: Staphylococcus aureus strain GDY8P96A

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IQE12_RS09620
• Protein ID: WP_001801861.1
• Coordinates: 1973988..1974083 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1974111..1974170 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQE12_RS09585	1969658..1970284	+	627	WP_000669017.1	hypothetical protein	-
IQE12_RS09590	1970325..1970666	+	342	WP_000627541.1	DUF3969 family protein	-
IQE12_RS09595	1970767..1971339	+	573	WP_000414202.1	hypothetical protein	-
IQE12_RS09600	1971537..1972094	-	558	Protein_1890	ImmA/IrrE family metallo-endopeptidase	-
IQE12_RS09605	1972468..1972644	-	177	WP_000375477.1	hypothetical protein	-
IQE12_RS09610	1972655..1973038	-	384	WP_000070811.1	hypothetical protein	-
IQE12_RS09615	1973642..1973785	-	144	WP_001549059.1	transposase	-
IQE12_RS09620	1973988..1974083	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1974111..1974170	-	60	-	-	Antitoxin
IQE12_RS09625	1974206..1974307	+	102	WP_001791893.1	hypothetical protein	-
IQE12_RS09630	1974285..1974461	-	177	Protein_1896	transposase	-
IQE12_RS09635	1974655..1975032	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T182857 WP_001801861.1 NZ_CP065515:1973988-1974083 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T182857 NZ_CP086616:3405857-3406243 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT182857 NZ_CP065515:c1974170-1974111 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin