Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 979483..979906 Replicon chromosome
Accession NZ_CP065515
Organism Staphylococcus aureus strain GDY8P96A

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag IQE12_RS04885 Protein ID WP_001065091.1
Coordinates 979483..979734 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag IQE12_RS04890 Protein ID WP_000028422.1
Coordinates 979724..979906 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE12_RS04820 974623..974772 + 150 WP_001081076.1 hypothetical protein -
IQE12_RS04825 974765..975046 - 282 WP_000414755.1 hypothetical protein -
IQE12_RS04830 975112..975882 + 771 WP_072362204.1 conserved phage C-terminal domain-containing protein -
IQE12_RS04835 975892..976671 + 780 WP_031836908.1 ATP-binding protein -
IQE12_RS04840 976665..976823 + 159 WP_181188017.1 hypothetical protein -
IQE12_RS04845 976836..977057 + 222 WP_001123685.1 DUF3269 family protein -
IQE12_RS04850 977068..977472 + 405 WP_181188016.1 DUF1064 domain-containing protein -
IQE12_RS04855 977477..977662 + 186 WP_001187234.1 DUF3113 family protein -
IQE12_RS04860 977663..978019 + 357 WP_181188015.1 hypothetical protein -
IQE12_RS04865 978023..978265 + 243 WP_181188014.1 phi PVL orf 51-like protein -
IQE12_RS04870 978279..978689 + 411 WP_181188013.1 hypothetical protein -
IQE12_RS04875 978686..979111 + 426 WP_181188012.1 hypothetical protein -
IQE12_RS04880 979125..979490 + 366 WP_181188011.1 acetyltransferase -
IQE12_RS04885 979483..979734 + 252 WP_001065091.1 DUF1024 family protein Toxin
IQE12_RS04890 979724..979906 + 183 WP_000028422.1 hypothetical protein Antitoxin
IQE12_RS04895 979899..980441 + 543 WP_181188010.1 dUTP pyrophosphatase -
IQE12_RS04900 980478..980678 + 201 WP_063651040.1 hypothetical protein -
IQE12_RS04905 980678..980881 + 204 WP_181188009.1 DUF1381 domain-containing protein -
IQE12_RS04910 980878..981081 + 204 WP_181188008.1 hypothetical protein -
IQE12_RS04915 981074..981310 + 237 WP_181188007.1 hypothetical protein -
IQE12_RS04920 981303..981476 + 174 WP_181188006.1 transcriptional activator RinB -
IQE12_RS04925 981477..981878 + 402 WP_033857049.1 hypothetical protein -
IQE12_RS04930 982254..982700 + 447 WP_031886350.1 terminase small subunit -
IQE12_RS04935 982687..983961 + 1275 WP_076692345.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 964256..1008622 44366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T182856 WP_001065091.1 NZ_CP065515:979483-979734 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T182856 NZ_CP086616:3150754-3151248 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT182856 WP_000028422.1 NZ_CP065515:979724-979906 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT182856 NZ_CP086616:3150464-3150757 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References