Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2510250..2510847 Replicon chromosome
Accession NZ_CP065467
Organism Klebsiella quasipneumoniae strain Pinhead Larry

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I5M56_RS12085 Protein ID WP_108450630.1
Coordinates 2510530..2510847 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I5M56_RS12080 Protein ID WP_108450629.1
Coordinates 2510250..2510537 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M56_RS12050 2506337..2506585 + 249 WP_002893037.1 DUF1158 domain-containing protein -
I5M56_RS12055 2506603..2506944 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
I5M56_RS12060 2506975..2508090 - 1116 WP_025999133.1 MBL fold metallo-hydrolase -
I5M56_RS12065 2508270..2508851 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
I5M56_RS12070 2508851..2509219 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
I5M56_RS12075 2509339..2509992 + 654 WP_108450628.1 oxygen-insensitive NAD(P)H nitroreductase -
I5M56_RS12080 2510250..2510537 - 288 WP_108450629.1 helix-turn-helix transcriptional regulator Antitoxin
I5M56_RS12085 2510530..2510847 - 318 WP_108450630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5M56_RS12090 2511031..2512074 - 1044 WP_108450631.1 DUF2157 domain-containing protein -
I5M56_RS12095 2512607..2513476 - 870 WP_004202474.1 helix-turn-helix transcriptional regulator -
I5M56_RS12100 2513585..2515012 + 1428 WP_004202473.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12197.57 Da        Isoelectric Point: 11.2767

>T182822 WP_108450630.1 NZ_CP065467:c2510847-2510530 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKIPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T182822 NZ_CP086604:4166434-4166769 [Escherichia fergusonii]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGTGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.56 Da        Isoelectric Point: 10.4518

>AT182822 WP_108450629.1 NZ_CP065467:c2510537-2510250 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERKHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT182822 NZ_CP086604:4166186-4166434 [Escherichia fergusonii]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References