Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/MqsA(antitoxin) |
| Location | 1190247..1190915 | Replicon | chromosome |
| Accession | NZ_CP065404 | ||
| Organism | Paraburkholderia caribensis strain IAC-BECa88 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | I5286_RS21760 | Protein ID | WP_227246035.1 |
| Coordinates | 1190247..1190588 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | I5286_RS21765 | Protein ID | WP_054933742.1 |
| Coordinates | 1190604..1190915 (+) | Length | 104 a.a. |
Genomic Context
Location: 1185866..1186843 (978 bp)
Type: Others
Protein ID: WP_054933738.1
Type: Others
Protein ID: WP_054933738.1
Location: 1186882..1187886 (1005 bp)
Type: Others
Protein ID: WP_060605483.1
Type: Others
Protein ID: WP_060605483.1
Location: 1187902..1189014 (1113 bp)
Type: Others
Protein ID: WP_054933739.1
Type: Others
Protein ID: WP_054933739.1
Location: 1189017..1189991 (975 bp)
Type: Others
Protein ID: WP_227246034.1
Type: Others
Protein ID: WP_227246034.1
Location: 1190247..1190588 (342 bp)
Type: Toxin
Protein ID: WP_227246035.1
Type: Toxin
Protein ID: WP_227246035.1
Location: 1190604..1190915 (312 bp)
Type: Antitoxin
Protein ID: WP_054933742.1
Type: Antitoxin
Protein ID: WP_054933742.1
Location: 1191010..1192476 (1467 bp)
Type: Others
Protein ID: WP_227246037.1
Type: Others
Protein ID: WP_227246037.1
Location: 1193384..1194667 (1284 bp)
Type: Others
Protein ID: WP_227246039.1
Type: Others
Protein ID: WP_227246039.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I5286_RS21740 | 1185866..1186843 | + | 978 | WP_054933738.1 | thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha | - |
| I5286_RS21745 | 1186882..1187886 | + | 1005 | WP_060605483.1 | alpha-ketoacid dehydrogenase subunit beta | - |
| I5286_RS21750 | 1187902..1189014 | + | 1113 | WP_054933739.1 | acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit | - |
| I5286_RS21755 | 1189017..1189991 | + | 975 | WP_227246034.1 | lipoyl synthase | - |
| I5286_RS21760 | 1190247..1190588 | + | 342 | WP_227246035.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I5286_RS21765 | 1190604..1190915 | + | 312 | WP_054933742.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I5286_RS21770 | 1191010..1192476 | - | 1467 | WP_227246037.1 | NAD-dependent succinate-semialdehyde dehydrogenase | - |
| I5286_RS21775 | 1193384..1194667 | - | 1284 | WP_227246039.1 | 4-aminobutyrate--2-oxoglutarate transaminase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13176.16 Da Isoelectric Point: 10.0622
>T182550 WP_227246035.1 NZ_CP065404:1190247-1190588 [Paraburkholderia caribensis]
MAATFVELGPFRRWRDDYLTDDEYRALQIVLMQNPEAGDVIRGTGGLRKLRFGDARRGKGKRGGLRVIYYYWVKGPEFWM
FTLYHKDEAEDLSSKGRGVLSEMLREVIKLANR
MAATFVELGPFRRWRDDYLTDDEYRALQIVLMQNPEAGDVIRGTGGLRKLRFGDARRGKGKRGGLRVIYYYWVKGPEFWM
FTLYHKDEAEDLSSKGRGVLSEMLREVIKLANR
Download Length: 342 bp
>T182550 NZ_CP086490:2755167-2755274 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11813.62 Da Isoelectric Point: 9.7238
>AT182550 WP_054933742.1 NZ_CP065404:1190604-1190915 [Paraburkholderia caribensis]
MKRNLLAELTEGLEDLKSAHEGKTTLHKVKVEIRDKLEVTAEEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL
MKRNLLAELTEGLEDLKSAHEGKTTLHKVKVEIRDKLEVTAEEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL
Download Length: 312 bp
>AT182550 NZ_CP086490:c2755120-2755054 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT