Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1190247..1190915 Replicon chromosome
Accession NZ_CP065404
Organism Paraburkholderia caribensis strain IAC-BECa88

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I5286_RS21760 Protein ID WP_227246035.1
Coordinates 1190247..1190588 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I5286_RS21765 Protein ID WP_054933742.1
Coordinates 1190604..1190915 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5286_RS21740 1185866..1186843 + 978 WP_054933738.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
I5286_RS21745 1186882..1187886 + 1005 WP_060605483.1 alpha-ketoacid dehydrogenase subunit beta -
I5286_RS21750 1187902..1189014 + 1113 WP_054933739.1 acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit -
I5286_RS21755 1189017..1189991 + 975 WP_227246034.1 lipoyl synthase -
I5286_RS21760 1190247..1190588 + 342 WP_227246035.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5286_RS21765 1190604..1190915 + 312 WP_054933742.1 helix-turn-helix domain-containing protein Antitoxin
I5286_RS21770 1191010..1192476 - 1467 WP_227246037.1 NAD-dependent succinate-semialdehyde dehydrogenase -
I5286_RS21775 1193384..1194667 - 1284 WP_227246039.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13176.16 Da        Isoelectric Point: 10.0622

>T182550 WP_227246035.1 NZ_CP065404:1190247-1190588 [Paraburkholderia caribensis]
MAATFVELGPFRRWRDDYLTDDEYRALQIVLMQNPEAGDVIRGTGGLRKLRFGDARRGKGKRGGLRVIYYYWVKGPEFWM
FTLYHKDEAEDLSSKGRGVLSEMLREVIKLANR

Download         Length: 342 bp

>T182550 NZ_CP086490:2755167-2755274 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11813.62 Da        Isoelectric Point: 9.7238

>AT182550 WP_054933742.1 NZ_CP065404:1190604-1190915 [Paraburkholderia caribensis]
MKRNLLAELTEGLEDLKSAHEGKTTLHKVKVEIRDKLEVTAEEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL

Download         Length: 312 bp

>AT182550 NZ_CP086490:c2755120-2755054 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References