Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 488222..488872 Replicon chromosome
Accession NZ_CP065386
Organism Glaesserella parasuis strain LHDR_HPS_1_2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I5Z97_RS02540 Protein ID WP_062923967.1
Coordinates 488534..488872 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I5Z97_RS02535 Protein ID WP_005710405.1
Coordinates 488222..488530 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5Z97_RS02515 484696..485184 - 489 WP_035496521.1 transcription elongation factor GreB -
I5Z97_RS02520 485184..486119 - 936 WP_005710401.1 KpsF/GutQ family sugar-phosphate isomerase -
I5Z97_RS02525 486180..486761 - 582 WP_005710402.1 type IV pilus biogenesis/stability protein PilW -
I5Z97_RS02530 486861..488021 - 1161 WP_010786053.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
I5Z97_RS02535 488222..488530 - 309 WP_005710405.1 helix-turn-helix domain-containing protein Antitoxin
I5Z97_RS02540 488534..488872 - 339 WP_062923967.1 toxin Toxin
I5Z97_RS02565 489711..491150 + 1440 WP_035496906.1 glutamate--tRNA ligase -
I5Z97_RS02575 491617..491883 - 267 Protein_480 cation-transporting ATPase PacS -
I5Z97_RS02580 491838..492762 - 925 Protein_481 transposase -
I5Z97_RS02585 492883..493257 - 375 WP_035496549.1 cytochrome B562 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-86)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13244.26 Da        Isoelectric Point: 9.8649

>T182511 WP_062923967.1 NZ_CP065386:c488872-488534 [Glaesserella parasuis]
MNVAFVELPPFEEYRKKYLDDDTFRLLQNELLKFPDKGELIQGTGGLRKLRIVDIIRQKGKRGGARVIYYYYVQGKQVWL
FHAYNKNQQDDLSNEERVVLANTLSYLKSLVR

Download         Length: 339 bp

>T182511 NZ_CP086480:933275-933682 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11539.61 Da        Isoelectric Point: 10.2919

>AT182511 WP_005710405.1 NZ_CP065386:c488530-488222 [Glaesserella parasuis]
MGKLFNELMEGMQALELHLQGKITLKTTVVEVPDPIVITPEEVKAIRQKLNLSQAVFARKLHTSVRTYQGWEQGRTKPNP
QAVLLLKMVEKSPKTFEQIASI

Download         Length: 309 bp

>AT182511 NZ_CP086480:933028-933294 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References