Detailed information of TA system TA182473

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2410578..2410762
• Replicon: chromosome
• Accession: NZ_CP065355
• Organism: Staphylococcus aureus strain JW31330_O1_dhc

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: I5046_RS11850
• Protein ID: WP_000482647.1
• Coordinates: 2410655..2410762 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2410578..2410638 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5046_RS11835 (I5046_11835)	2406013..2406180	-	168	WP_001789205.1	hypothetical protein	-
I5046_RS11840 (I5046_11840)	2406411..2408144	-	1734	WP_000486484.1	ABC transporter ATP-binding protein	-
I5046_RS11845 (I5046_11845)	2408169..2409932	-	1764	WP_001064819.1	ABC transporter ATP-binding protein	-
-	2410578..2410638	+	61	-	-	Antitoxin
I5046_RS11850 (I5046_11850)	2410655..2410762	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
I5046_RS11855 (I5046_11855)	2410896..2411282	-	387	WP_000779352.1	flippase GtxA	-
I5046_RS11860 (I5046_11860)	2411550..2412692	+	1143	WP_001176863.1	glycerate kinase	-
I5046_RS11865 (I5046_11865)	2412752..2413411	+	660	WP_000831298.1	membrane protein	-
I5046_RS11870 (I5046_11870)	2413594..2414805	+	1212	WP_001191923.1	multidrug effflux MFS transporter	-
I5046_RS11875 (I5046_11875)	2414928..2415401	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T182473 WP_000482647.1 NZ_CP065355:c2410762-2410655 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T182473 NZ_CP086467:c5374616-5374233 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT182473 NZ_CP065355:2410578-2410638 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin