182472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2385232..2385749 Replicon chromosome
Accession NZ_CP065355
Organism Staphylococcus aureus strain JW31330_O1_dhc

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag I5046_RS11715 Protein ID WP_000113263.1
Coordinates 2385232..2385498 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag I5046_RS11720 Protein ID WP_000584498.1
Coordinates 2385498..2385749 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5046_RS11690 (I5046_11690) 2380438..2380974 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
I5046_RS11695 (I5046_11695) 2381439..2382263 - 825 WP_000594640.1 formate/nitrite transporter family protein -
I5046_RS11700 (I5046_11700) 2382466..2382648 - 183 WP_000079140.1 hypothetical protein -
I5046_RS11705 (I5046_11705) 2382735..2383202 - 468 WP_000153340.1 SRPBCC domain-containing protein -
I5046_RS11710 (I5046_11710) 2383388..2384938 - 1551 WP_029754332.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
I5046_RS13440 2385126..2385197 - 72 WP_223200558.1 hypothetical protein -
I5046_RS11715 (I5046_11715) 2385232..2385498 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
I5046_RS11720 (I5046_11720) 2385498..2385749 - 252 WP_000584498.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I5046_RS11725 (I5046_11725) 2385920..2386011 - 92 Protein_2276 hypothetical protein -
I5046_RS11730 (I5046_11730) 2386018..2386617 - 600 WP_000162810.1 DsbA family protein -
I5046_RS11735 (I5046_11735) 2386636..2386998 - 363 WP_000819844.1 DUF4467 domain-containing protein -
I5046_RS11740 (I5046_11740) 2387253..2388503 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
I5046_RS11745 (I5046_11745) 2388600..2389331 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
I5046_RS11750 (I5046_11750) 2389328..2390047 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T182472 WP_000113263.1 NZ_CP065355:c2385498-2385232 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T182472 NZ_CP086467:c5051186-5050269 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9449.64 Da        Isoelectric Point: 4.3407

>AT182472 WP_000584498.1 NZ_CP065355:c2385749-2385498 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNLNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT182472 NZ_CP086467:c5051950-5051192 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure

References