Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 1888089..1888344 Replicon chromosome
Accession NZ_CP065355
Organism Staphylococcus aureus strain JW31330_O1_dhc

Toxin (Protein)


Gene name SprG2 Uniprot ID -
Locus tag I5046_RS09075 Protein ID WP_000255427.1
Coordinates 1888237..1888344 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1888089..1888226 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5046_RS09040 (I5046_09040) 1883380..1883994 - 615 WP_196957482.1 hypothetical protein -
I5046_RS09045 (I5046_09045) 1883991..1884167 - 177 WP_000201922.1 hypothetical protein -
I5046_RS09050 (I5046_09050) 1884774..1885742 - 969 WP_000669582.1 bi-component leukocidin LukMF' subunit F' -
I5046_RS09055 (I5046_09055) 1885744..1886670 - 927 WP_000476436.1 bi-component leukocidin LukMF' subunit M -
I5046_RS09060 (I5046_09060) 1887018..1887773 - 756 WP_000861033.1 CHAP domain-containing protein -
I5046_RS09065 (I5046_09065) 1887785..1888039 - 255 WP_000611513.1 phage holin -
- 1888089..1888226 + 138 - - Antitoxin
I5046_RS09075 (I5046_09075) 1888237..1888344 - 108 WP_000255427.1 putative holin-like toxin Toxin
I5046_RS09080 (I5046_09080) 1888578..1888874 - 297 WP_000539688.1 DUF2951 domain-containing protein -
I5046_RS09085 (I5046_09085) 1888932..1889219 - 288 WP_001040260.1 hypothetical protein -
I5046_RS09090 (I5046_09090) 1889266..1889418 - 153 WP_001153680.1 hypothetical protein -
I5046_RS09095 (I5046_09095) 1889408..1893193 - 3786 WP_123138794.1 phage tail spike protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / lukS-PV 1879983..1923703 43720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3800.75 Da        Isoelectric Point: 10.4997

>T182467 WP_000255427.1 NZ_CP065355:c1888344-1888237 [Staphylococcus aureus]
VVSVVDALNLMFSFGMFIVALLGLVIAIVKLNHKK

Download         Length: 108 bp

>T182467 NZ_CP086467:c3029451-3029349 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 138 bp

>AT182467 NZ_CP065355:1888089-1888226 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGCAACATGCGCAAACATGTTACCTTAATGAGCCCG
TTAAAAAGACGGTGGCTCAGTTTTGAAATTATTATAAAATAACCATTAACCGTCCAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References