Detailed information of TA system TA182464

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1798717..1798897
• Replicon: chromosome
• Accession: NZ_CP065355
• Organism: Staphylococcus aureus strain JW31330_O1_dhc

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: I5046_RS08460
• Protein ID: WP_001801861.1
• Coordinates: 1798717..1798812 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1798840..1798897 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5046_RS08420 (I5046_08420)	1794183..1795178	+	996	WP_020977362.1	DUF4352 domain-containing protein	-
I5046_RS08425 (I5046_08425)	1795254..1795880	+	627	WP_000669045.1	hypothetical protein	-
I5046_RS08430 (I5046_08430)	1795921..1796262	+	342	WP_000627534.1	DUF3969 family protein	-
I5046_RS08435 (I5046_08435)	1796363..1796935	+	573	WP_000414218.1	hypothetical protein	-
I5046_RS08440 (I5046_08440)	1797453..1797629	-	177	WP_000375478.1	hypothetical protein	-
I5046_RS08445 (I5046_08445)	1797640..1797962	-	323	Protein_1666	hypothetical protein	-
I5046_RS13400	1797989..1798192	-	204	WP_225970890.1	IS3 family transposase	-
I5046_RS08455 (I5046_08455)	1798336..1798572	-	237	WP_000251969.1	IS3 family transposase	-
I5046_RS08460 (I5046_08460)	1798717..1798812	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1798840..1798897	-	58	-	-	Antitoxin
I5046_RS13405	1798935..1798999	+	65	Protein_1670	hypothetical protein	-
I5046_RS08465 (I5046_08465)	1799028..1799183	+	156	WP_001215823.1	hypothetical protein	-
I5046_RS08470 (I5046_08470)	1799753..1800196	-	444	WP_000728661.1	DUF1433 domain-containing protein	-
I5046_RS08475 (I5046_08475)	1800196..1800639	-	444	WP_000731420.1	DUF1433 domain-containing protein	-
I5046_RS08480 (I5046_08480)	1800639..1801082	-	444	WP_000747798.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1798336..1798572	236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T182464 WP_001801861.1 NZ_CP065355:1798717-1798812 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T182464 NZ_CP086467:805744-806154 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT182464 NZ_CP065355:c1798897-1798840 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin