Detailed information of TA system TA182461

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2420951..2421135
• Replicon: chromosome
• Accession: NZ_CP065354
• Organism: Staphylococcus aureus strain JW_comp_novo

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: I5044_RS11875
• Protein ID: WP_000482647.1
• Coordinates: 2421028..2421135 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2420951..2421011 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5044_RS11860 (I5044_11860)	2416386..2416553	-	168	WP_001789205.1	hypothetical protein	-
I5044_RS11865 (I5044_11865)	2416784..2418517	-	1734	WP_000486484.1	ABC transporter ATP-binding protein	-
I5044_RS11870 (I5044_11870)	2418542..2420305	-	1764	WP_001064819.1	ABC transporter ATP-binding protein	-
-	2420951..2421011	+	61	-	-	Antitoxin
I5044_RS11875 (I5044_11875)	2421028..2421135	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
I5044_RS11880 (I5044_11880)	2421269..2421655	-	387	WP_000779352.1	flippase GtxA	-
I5044_RS11885 (I5044_11885)	2421923..2423065	+	1143	WP_001176863.1	glycerate kinase	-
I5044_RS11890 (I5044_11890)	2423125..2423784	+	660	WP_000831298.1	membrane protein	-
I5044_RS11895 (I5044_11895)	2423967..2425178	+	1212	WP_001191923.1	multidrug effflux MFS transporter	-
I5044_RS11900 (I5044_11900)	2425301..2425774	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T182461 WP_000482647.1 NZ_CP065354:c2421135-2421028 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T182461 NZ_CP086465:53928-54410 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT182461 NZ_CP065354:2420951-2421011 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin