Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1864104..1864506 Replicon chromosome
Accession NZ_CP065354
Organism Staphylococcus aureus strain JW_comp_novo

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I5044_RS08840 Protein ID WP_196957579.1
Coordinates 1864255..1864506 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I5044_RS08835 Protein ID WP_196957578.1
Coordinates 1864104..1864265 (-) Length 54 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5044_RS08790 (I5044_08790) 1860089..1861363 - 1275 WP_196957576.1 PBSX family phage terminase large subunit -
I5044_RS08795 (I5044_08795) 1861350..1861796 - 447 WP_196957577.1 terminase small subunit -
I5044_RS08800 (I5044_08800) 1862120..1862542 - 423 WP_000162701.1 RinA family phage transcriptional activator -
I5044_RS08805 (I5044_08805) 1862566..1862712 - 147 WP_031792584.1 hypothetical protein -
I5044_RS08810 (I5044_08810) 1862713..1862886 - 174 WP_000595258.1 transcriptional activator RinB -
I5044_RS08815 (I5044_08815) 1862883..1863089 - 207 WP_033859700.1 DUF1381 domain-containing protein -
I5044_RS08820 (I5044_08820) 1863126..1863632 - 507 WP_001061842.1 dUTPase -
I5044_RS08825 (I5044_08825) 1863647..1863808 - 162 WP_000889683.1 hypothetical protein -
I5044_RS08830 (I5044_08830) 1863809..1864090 - 282 WP_000454994.1 hypothetical protein -
I5044_RS08835 (I5044_08835) 1864104..1864265 - 162 WP_196957578.1 hypothetical protein Antitoxin
I5044_RS08840 (I5044_08840) 1864255..1864506 - 252 WP_196957579.1 DUF1024 family protein Toxin
I5044_RS08845 (I5044_08845) 1864499..1864828 - 330 WP_231386128.1 hypothetical protein -
I5044_RS08850 (I5044_08850) 1864825..1865334 - 510 WP_231386129.1 hypothetical protein -
I5044_RS08855 (I5044_08855) 1865350..1865598 - 249 WP_196957581.1 SAV1978 family virulence-associated passenger protein -
I5044_RS08860 (I5044_08860) 1865599..1865949 - 351 WP_196957582.1 SA1788 family PVL leukocidin-associated protein -
I5044_RS08865 (I5044_08865) 1865950..1866135 - 186 WP_162636291.1 DUF3113 family protein -
I5044_RS08870 (I5044_08870) 1866140..1866544 - 405 WP_196957583.1 DUF1064 domain-containing protein -
I5044_RS08875 (I5044_08875) 1866555..1866776 - 222 WP_196957584.1 DUF3269 family protein -
I5044_RS08880 (I5044_08880) 1866789..1866947 - 159 WP_000628833.1 hypothetical protein -
I5044_RS08885 (I5044_08885) 1866944..1867729 - 786 WP_000443354.1 ATP-binding protein -
I5044_RS08890 (I5044_08890) 1867742..1868563 - 822 WP_000504984.1 phage replisome organizer N-terminal domain-containing protein -
I5044_RS08895 (I5044_08895) 1868535..1869230 - 696 WP_196957585.1 putative HNHc nuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1817518..1877598 60080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9460.40 Da        Isoelectric Point: 3.9373

>T182456 WP_196957579.1 NZ_CP065354:c1864506-1864255 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEEVYKKAQAFDEILKGLHNAMQDALKEDIGLDEAVGIMTSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T182456 NZ_CP086464:c4766935-4766402 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 54 a.a.        Molecular weight: 6026.81 Da        Isoelectric Point: 4.3046

>AT182456 WP_196957578.1 NZ_CP065354:c1864265-1864104 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLT

Download         Length: 162 bp

>AT182456 NZ_CP086464:c4767212-4766946 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References