Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1812144..1812324 Replicon chromosome
Accession NZ_CP065354
Organism Staphylococcus aureus strain JW_comp_novo

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag I5044_RS08550 Protein ID WP_001801861.1
Coordinates 1812144..1812239 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1812267..1812324 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5044_RS08510 (I5044_08510) 1807610..1808605 + 996 WP_020977362.1 DUF4352 domain-containing protein -
I5044_RS08515 (I5044_08515) 1808681..1809307 + 627 WP_000669045.1 hypothetical protein -
I5044_RS08520 (I5044_08520) 1809348..1809689 + 342 WP_000627534.1 DUF3969 family protein -
I5044_RS08525 (I5044_08525) 1809790..1810362 + 573 WP_000414218.1 hypothetical protein -
I5044_RS08530 (I5044_08530) 1810880..1811056 - 177 WP_000375478.1 hypothetical protein -
I5044_RS08535 (I5044_08535) 1811067..1811389 - 323 Protein_1682 hypothetical protein -
I5044_RS13435 1811416..1811619 - 204 WP_225970890.1 IS3 family transposase -
I5044_RS08545 (I5044_08545) 1811763..1811999 - 237 WP_000251969.1 IS3 family transposase -
I5044_RS08550 (I5044_08550) 1812144..1812239 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1812267..1812324 - 58 - - Antitoxin
I5044_RS13440 1812362..1812426 + 65 Protein_1686 hypothetical protein -
I5044_RS08555 (I5044_08555) 1812455..1812610 + 156 WP_001215823.1 hypothetical protein -
I5044_RS08560 (I5044_08560) 1813179..1813622 - 444 WP_000728661.1 DUF1433 domain-containing protein -
I5044_RS08565 (I5044_08565) 1813622..1814065 - 444 WP_000731420.1 DUF1433 domain-containing protein -
I5044_RS08570 (I5044_08570) 1814065..1814508 - 444 WP_000747798.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1811763..1811999 236


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T182454 WP_001801861.1 NZ_CP065354:1812144-1812239 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T182454 NZ_CP086464:c3029450-3029348 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT182454 NZ_CP065354:c1812324-1812267 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References