Detailed information of TA system TA182450

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2422337..2422521
• Replicon: chromosome
• Accession: NZ_CP065353
• Organism: Staphylococcus aureus strain AR39_O1_merpol

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: I5043_RS11840
• Protein ID: WP_000482647.1
• Coordinates: 2422414..2422521 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2422337..2422397 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5043_RS11825 (I5043_11825)	2417791..2417958	-	168	WP_041204334.1	hypothetical protein	-
I5043_RS11830 (I5043_11830)	2418189..2419922	-	1734	WP_196931773.1	ABC transporter ATP-binding protein	-
I5043_RS11835 (I5043_11835)	2419947..2421710	-	1764	WP_001064817.1	ABC transporter ATP-binding protein	-
-	2422337..2422397	+	61	-	-	Antitoxin
I5043_RS11840 (I5043_11840)	2422414..2422521	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
I5043_RS11845 (I5043_11845)	2422655..2423041	-	387	WP_000779350.1	flippase GtxA	-
I5043_RS11850 (I5043_11850)	2423309..2424451	+	1143	WP_001176868.1	glycerate kinase	-
I5043_RS11855 (I5043_11855)	2424511..2425170	+	660	WP_000831299.1	hypothetical protein	-
I5043_RS11860 (I5043_11860)	2425355..2426566	+	1212	WP_001191928.1	multidrug effflux MFS transporter	-
I5043_RS11865 (I5043_11865)	2426689..2427162	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgA / hlgC / hlgB	2407112..2423041	15929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T182450 WP_000482647.1 NZ_CP065353:c2422521-2422414 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T182450 NZ_CP086464:360636-360983 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT182450 NZ_CP065353:2422337-2422397 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin