Detailed information of TA system TA182449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2396667..2397184
• Replicon: chromosome
• Accession: NZ_CP065353
• Organism: Staphylococcus aureus strain AR39_O1_merpol

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I5043_RS11705
• Protein ID: WP_000375483.1
• Coordinates: 2396667..2396933 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: I5043_RS11710
• Protein ID: WP_000584499.1
• Coordinates: 2396933..2397184 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5043_RS11680 (I5043_11680)	2391815..2392351	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
I5043_RS11685 (I5043_11685)	2392871..2393695	-	825	WP_000594631.1	formate/nitrite transporter family protein	-
I5043_RS11690 (I5043_11690)	2393898..2394080	-	183	WP_000079140.1	hypothetical protein	-
I5043_RS11695 (I5043_11695)	2394167..2394634	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
I5043_RS11700 (I5043_11700)	2394820..2396373	-	1554	WP_000727769.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
I5043_RS13360	2396552..2396650	-	99	WP_224089274.1	hypothetical protein	-
I5043_RS11705 (I5043_11705)	2396667..2396933	-	267	WP_000375483.1	Txe/YoeB family addiction module toxin	Toxin
I5043_RS11710 (I5043_11710)	2396933..2397184	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I5043_RS11715 (I5043_11715)	2397348..2397448	-	101	Protein_2274	hypothetical protein	-
I5043_RS11720 (I5043_11720)	2397455..2398054	-	600	WP_000162810.1	DsbA family protein	-
I5043_RS11725 (I5043_11725)	2398073..2398435	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
I5043_RS11730 (I5043_11730)	2398690..2399940	+	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
I5043_RS11735 (I5043_11735)	2400033..2400764	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
I5043_RS11740 (I5043_11740)	2400761..2401480	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10450.05 Da
• Isoelectric Point: 10.2538

>T182449 WP_000375483.1 NZ_CP065353:c2396933-2396667 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T182449 NZ_CP086464:334675-335043 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT182449 WP_000584499.1 NZ_CP065353:c2397184-2396933 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT182449 NZ_CP086464:334457-334678 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: T1YB60