Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2396667..2397184 | Replicon | chromosome |
| Accession | NZ_CP065353 | ||
| Organism | Staphylococcus aureus strain AR39_O1_merpol | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | I5043_RS11705 | Protein ID | WP_000375483.1 |
| Coordinates | 2396667..2396933 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | I5043_RS11710 | Protein ID | WP_000584499.1 |
| Coordinates | 2396933..2397184 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I5043_RS11680 (I5043_11680) | 2391815..2392351 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| I5043_RS11685 (I5043_11685) | 2392871..2393695 | - | 825 | WP_000594631.1 | formate/nitrite transporter family protein | - |
| I5043_RS11690 (I5043_11690) | 2393898..2394080 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| I5043_RS11695 (I5043_11695) | 2394167..2394634 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| I5043_RS11700 (I5043_11700) | 2394820..2396373 | - | 1554 | WP_000727769.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| I5043_RS13360 | 2396552..2396650 | - | 99 | WP_224089274.1 | hypothetical protein | - |
| I5043_RS11705 (I5043_11705) | 2396667..2396933 | - | 267 | WP_000375483.1 | Txe/YoeB family addiction module toxin | Toxin |
| I5043_RS11710 (I5043_11710) | 2396933..2397184 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| I5043_RS11715 (I5043_11715) | 2397348..2397448 | - | 101 | Protein_2274 | hypothetical protein | - |
| I5043_RS11720 (I5043_11720) | 2397455..2398054 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| I5043_RS11725 (I5043_11725) | 2398073..2398435 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| I5043_RS11730 (I5043_11730) | 2398690..2399940 | + | 1251 | WP_001012239.1 | FemA/FemB family glycyltransferase FmhA | - |
| I5043_RS11735 (I5043_11735) | 2400033..2400764 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| I5043_RS11740 (I5043_11740) | 2400761..2401480 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10450.05 Da Isoelectric Point: 10.2538
>T182449 WP_000375483.1 NZ_CP065353:c2396933-2396667 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY
Download Length: 267 bp
>T182449 NZ_CP086464:334675-335043 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT182449 WP_000584499.1 NZ_CP065353:c2397184-2396933 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT182449 NZ_CP086464:334457-334678 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|