Detailed information of TA system TA182448

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2132128..2132326
• Replicon: chromosome
• Accession: NZ_CP065353
• Organism: Staphylococcus aureus strain AR39_O1_merpol

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: I5043_RS10360
• Protein ID: WP_001802298.1
• Coordinates: 2132222..2132326 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2132128..2132166 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5043_RS10340 (I5043_10340)	2128295..2128960	-	666	WP_001024100.1	SDR family oxidoreductase	-
I5043_RS10345 (I5043_10345)	2129112..2129432	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I5043_RS10350 (I5043_10350)	2129434..2130414	+	981	WP_000019740.1	CDF family zinc efflux transporter CzrB	-
I5043_RS10355 (I5043_10355)	2130680..2131771	+	1092	WP_000495692.1	hypothetical protein	-
I5043_RS13350	2132108..2132182	+	75	Protein_2010	hypothetical protein	-
-	2132128..2132166	+	39	-	-	Antitoxin
I5043_RS10360 (I5043_10360)	2132222..2132326	-	105	WP_001802298.1	hypothetical protein	Toxin
I5043_RS10365 (I5043_10365)	2132487..2132970	-	484	Protein_2012	recombinase family protein	-
I5043_RS10370 (I5043_10370)	2133013..2134133	-	1121	Protein_2013	SAP domain-containing protein	-
I5043_RS10375 (I5043_10375)	2135182..2136039	-	858	WP_000370943.1	HAD family hydrolase	-
I5043_RS10380 (I5043_10380)	2136107..2136889	-	783	WP_000909235.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T182448 WP_001802298.1 NZ_CP065353:c2132326-2132222 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T182448 NZ_CP086462:53928-54410 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Nucleotide

• Length: 39 bp

>AT182448 NZ_CP065353:2132128-2132166 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin