Detailed information of TA system TA182443

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1793344..1793524
• Replicon: chromosome
• Accession: NZ_CP065353
• Organism: Staphylococcus aureus strain AR39_O1_merpol

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: I5043_RS08400
• Protein ID: WP_001801861.1
• Coordinates: 1793344..1793439 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1793467..1793524 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5043_RS08375 (I5043_08375)	1788747..1789373	+	627	WP_000669034.1	hypothetical protein	-
I5043_RS08380 (I5043_08380)	1789414..1789755	+	342	WP_000627544.1	DUF3969 family protein	-
I5043_RS08385 (I5043_08385)	1789856..1790428	+	573	WP_000414210.1	hypothetical protein	-
I5043_RS08390 (I5043_08390)	1790804..1791640	+	837	WP_000190484.1	ATP-binding cassette domain-containing protein	-
I5043_RS08395 (I5043_08395)	1792447..1792893	-	447	WP_000747806.1	DUF1433 domain-containing protein	-
I5043_RS08400 (I5043_08400)	1793344..1793439	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1793467..1793524	-	58	-	-	Antitoxin
I5043_RS08405 (I5043_08405)	1793562..1793663	+	102	WP_001791232.1	hypothetical protein	-
I5043_RS08410 (I5043_08410)	1793649..1793828	-	180	Protein_1661	transposase	-
I5043_RS08415 (I5043_08415)	1794016..1794390	-	375	WP_000695817.1	DUF1433 domain-containing protein	-
I5043_RS08420 (I5043_08420)	1794380..1794760	-	381	WP_001035978.1	DUF1433 domain-containing protein	-
I5043_RS08425 (I5043_08425)	1794968..1795408	-	441	WP_000759945.1	DUF1433 domain-containing protein	-
I5043_RS08430 (I5043_08430)	1795453..1797066	+	1614	WP_065316741.1	lipase	-
I5043_RS08435 (I5043_08435)	1797081..1797380	+	300	WP_000095391.1	WXG100 family type VII secretion target	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / lukS-PV / lukS-PV	1786187..1825016	38829

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T182443 WP_001801861.1 NZ_CP065353:1793344-1793439 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T182443 NZ_CP086461:c4766945-4766412 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT182443 NZ_CP065353:c1793524-1793467 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin