Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2009979..2010568 Replicon chromosome
Accession NZ_CP065228
Organism Xanthomonas oryzae pv. oryzae strain BXO512

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag BXO512_RS09405 Protein ID WP_012443754.1
Coordinates 2010287..2010568 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BXO512_RS09400 Protein ID WP_011260746.1
Coordinates 2009979..2010269 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BXO512_RS09370 (BXO512_009280) 2005264..2005740 - 477 WP_011260741.1 DUF4123 domain-containing protein -
BXO512_RS09375 (BXO512_009285) 2005743..2006165 - 423 WP_033013301.1 PAAR domain-containing protein -
BXO512_RS09380 (BXO512_009290) 2006293..2006619 - 327 WP_237384726.1 hypothetical protein -
BXO512_RS09385 (BXO512_009295) 2006874..2007206 + 333 WP_011260743.1 hypothetical protein -
BXO512_RS09390 2007366..2007553 + 188 Protein_1794 hypothetical protein -
BXO512_RS09395 (BXO512_009300) 2007656..2009050 - 1395 WP_075240796.1 type III secretion system effector XopQ -
BXO512_RS09400 (BXO512_009305) 2009979..2010269 - 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
BXO512_RS09405 (BXO512_009310) 2010287..2010568 - 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BXO512_RS09410 (BXO512_009315) 2010663..2012921 - 2259 WP_075240794.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1988694..2028353 39659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T182324 WP_012443754.1 NZ_CP065228:c2010568-2010287 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T182324 NZ_CP086408:c2873037-2872934 [Enterobacter cloacae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT182324 WP_011260746.1 NZ_CP065228:c2010269-2009979 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT182324 NZ_CP086408:2872921-2873072 [Enterobacter cloacae]
CTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References