Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4933659..4934250 Replicon chromosome
Accession NZ_CP065202
Organism Pseudomonas fragi strain A13BB

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I5R27_RS22555 Protein ID WP_029611627.1
Coordinates 4933972..4934250 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag I5R27_RS22550 Protein ID WP_016782667.1
Coordinates 4933659..4933964 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5R27_RS22520 4929117..4929803 + 687 WP_016782662.1 HAD family hydrolase -
I5R27_RS22525 4929990..4930316 - 327 WP_016782663.1 hypothetical protein -
I5R27_RS22530 4930795..4932132 - 1338 WP_083369719.1 ammonium transporter -
I5R27_RS22535 4932166..4932504 - 339 WP_002555808.1 P-II family nitrogen regulator -
I5R27_RS22540 4932922..4933182 + 261 WP_016782665.1 accessory factor UbiK family protein -
I5R27_RS22545 4933229..4933657 + 429 WP_016782666.1 VOC family protein -
I5R27_RS22550 4933659..4933964 - 306 WP_016782667.1 HigA family addiction module antidote protein Antitoxin
I5R27_RS22555 4933972..4934250 - 279 WP_029611627.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5R27_RS22560 4934427..4935920 + 1494 WP_086795630.1 YifB family Mg chelatase-like AAA ATPase -
I5R27_RS22565 4935930..4936850 - 921 WP_106115657.1 LysR family transcriptional regulator -
I5R27_RS22570 4937003..4938403 + 1401 WP_086799514.1 NorM family multidrug efflux MATE transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10437.11 Da        Isoelectric Point: 10.0073

>T182315 WP_029611627.1 NZ_CP065202:c4934250-4933972 [Pseudomonas fragi]
MIVSFKCNRTERLYRSGKTRLWSDILNVIERKLTMLDAASVLTDLASPPGNRLEALGGARKGQYSIRINAQWRICFIWGA
KGPEAVEIVDYH

Download         Length: 279 bp

>T182315 NZ_CP086405:c4722690-4722319 [Enterobacter roggenkampii]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GAATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTGATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATCCTAGCTACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11136.88 Da        Isoelectric Point: 7.2438

>AT182315 WP_016782667.1 NZ_CP065202:c4933964-4933659 [Pseudomonas fragi]
MIKNGMRPVHPGEVLKEEYLEPLSLSSAALARALGVSTPTVNDIVLQRRGVSADMALRLSVCLGTTPEFWLNLQTTYDLR
KAEIDRGAAIREQVQPIHHCA

Download         Length: 306 bp

>AT182315 NZ_CP086405:c4722935-4722693 [Enterobacter roggenkampii]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAACCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGCGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References