Detailed information of TA system TA182309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2465502..2466025
• Replicon: chromosome
• Accession: NZ_CP065199
• Organism: Staphylococcus aureus strain DG36

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: I3K83_RS12110
• Protein ID: WP_000074043.1
• Coordinates: 2465502..2465768 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: I3K83_RS12115
• Protein ID: WP_000587618.1
• Coordinates: 2465768..2466025 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K83_RS12090	2460808..2461995	-	1188	WP_000026194.1	MFS transporter	-
I3K83_RS12095	2462391..2463167	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
I3K83_RS12100	2463160..2463822	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
I3K83_RS12105	2464070..2465146	-	1077	WP_001076673.1	M42 family metallopeptidase	-
I3K83_RS12110	2465502..2465768	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
I3K83_RS12115	2465768..2466025	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I3K83_RS12120	2466384..2466839	+	456	WP_000732076.1	DUF1307 domain-containing protein	-
I3K83_RS12125	2467007..2468584	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
I3K83_RS12130	2468779..2469528	+	750	WP_000072466.1	hypothetical protein	-
I3K83_RS12135	2469759..2470952	-	1194	WP_031775427.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T182309 WP_000074043.1 NZ_CP065199:c2465768-2465502 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T182309 NZ_CP086405:605687-605974 [Enterobacter roggenkampii]
ATGCCAATGGAGTATGAGTGGGATAACAATAAGGCGAAAAGTAACCTGCAAAAACATGGCATACGCTTTGAGGATGCGGT
TATGGTTTTCGACGATCCTTATCATTTGTCTGTTCAGGATCGCTATGAAAACGGGGAATTTCGCTGGCAAACCATCGGCC
TTGTGCAAGGCCTTCTTGTTATTTTGGTCGCACATACGGTACGTTTTGAAAGCGGAGGAGAAATCATCCGTATCATTAGC
GCACGAAAGGCGGACCGCAAAGAGAGGAGCCGTTATGAGCATCGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT182309 WP_000587618.1 NZ_CP065199:c2466025-2465768 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT182309 NZ_CP086405:605961-606263 [Enterobacter roggenkampii]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCGCCTGAGGTAAGCGCTCGTCGTGTGGCTGAGCTCAAAGCATTAGCTGA
AAAACCAGATGCGGAGATTGATTACAGCGATATTCCTGCCACGGACGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGACCACTCAAAACTCAGGCATCTGTACGCATTGACGCCGATGTGATGGAGTGGCTTAAACGGCCTGGGAAAGGT
TATCAGACGCGGCTCAATGCCATTTTGCGTGAAGCAATGCTGCGCGATCAAAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2