Detailed information of TA system TA182307

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2433838..2434022
• Replicon: chromosome
• Accession: NZ_CP065199
• Organism: Staphylococcus aureus strain DG36

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: I3K83_RS11970
• Protein ID: WP_000482647.1
• Coordinates: 2433915..2434022 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2433838..2433898 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K83_RS11955	2429368..2429535	-	168	WP_001790576.1	hypothetical protein	-
I3K83_RS11960	2429766..2431499	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
I3K83_RS11965	2431524..2433287	-	1764	WP_001064816.1	ABC transporter ATP-binding protein/permease	-
-	2433838..2433898	+	61	-	-	Antitoxin
I3K83_RS11970	2433915..2434022	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
I3K83_RS11975	2434156..2434542	-	387	WP_000779360.1	flippase GtxA	-
I3K83_RS11980	2434800..2435942	+	1143	WP_001176863.1	glycerate kinase	-
I3K83_RS11985	2436002..2436661	+	660	WP_000831298.1	membrane protein	-
I3K83_RS11990	2436843..2438054	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
I3K83_RS11995	2438177..2438650	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T182307 WP_000482647.1 NZ_CP065199:c2434022-2433915 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T182307 NZ_CP086405:c257593-257306 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT182307 NZ_CP065199:2433838-2433898 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin