Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2408605..2409122 Replicon chromosome
Accession NZ_CP065199
Organism Staphylococcus aureus strain DG36

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag I3K83_RS11835 Protein ID WP_000113262.1
Coordinates 2408605..2408871 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag I3K83_RS11840 Protein ID WP_000584499.1
Coordinates 2408871..2409122 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3K83_RS11810 2404030..2404566 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
I3K83_RS11815 2404799..2405623 - 825 WP_000572040.1 formate/nitrite transporter family protein -
I3K83_RS11820 2405840..2406022 - 183 WP_000230294.1 hypothetical protein -
I3K83_RS11825 2406106..2406573 - 468 WP_000153344.1 SRPBCC domain-containing protein -
I3K83_RS11830 2406759..2408309 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
I3K83_RS11835 2408605..2408871 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
I3K83_RS11840 2408871..2409122 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I3K83_RS11845 2409287..2409388 - 102 WP_031774922.1 hypothetical protein -
I3K83_RS11850 2409395..2409994 - 600 WP_000162813.1 DsbA family protein -
I3K83_RS11855 2410013..2410375 - 363 WP_000819843.1 DUF4467 domain-containing protein -
I3K83_RS11860 2410630..2411880 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
I3K83_RS11865 2411977..2412708 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
I3K83_RS11870 2412705..2413424 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T182306 WP_000113262.1 NZ_CP065199:c2408871-2408605 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T182306 NZ_CP086393:2975798-2976148 [Paenibacillus macerans]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTCTCTCCTGTCGTTGGATCAGAGCAGGGCGGGGTAAGACCTGT
GCTTATCATCCAGAATGATATCGGCAATCGATTTAGCCCTACGGCCATTGTTGCCGCTATTACGGCACAAATCCAAAAAG
CAAAGCTGCCGACCCATGTGGAGATCGATGCGGCTACGCACGGATTTGACAGGGATTCCGTGATTTTGCTGGAACAGATA
CGTACGATCGACAAACAACGACTTACCGATAAAATTACCCATTTGGACGAAGAGACGATGAAAAAAGTTAACGATTCGCT
GCTGATTAGTCTCGGTTTGATCGATTTTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT182306 WP_000584499.1 NZ_CP065199:c2409122-2408871 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT182306 NZ_CP086393:2975513-2975794 [Paenibacillus macerans]
ATGGCCAATATGCACAACACCAAAAGAATCATGATCAGTTTGCCGGATCATCTTTTGCAGGAAGTGGATGGGATCGTTGC
GATGGAAAATTCCAACCGCAGCGAGTTGATCAGACAGGCCATGAAGCTGTATCTGAACGAACGCAAGAAGCGGTTCATTC
GCGAATCGATGCAGCGCGGGTATATGGAGATGGCTAAAATCAATTTGTCCATGGCCTCGGAAGCATTCCATGCGGAGGAA
GATGCAGACATCACTCTGGACCGCCTAGTAAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References