Detailed information of TA system TA182305

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2149414..2149611
• Replicon: chromosome
• Accession: NZ_CP065199
• Organism: Staphylococcus aureus strain DG36

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: I3K83_RS10490
• Protein ID: WP_001802298.1
• Coordinates: 2149507..2149611 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2149414..2149452 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K83_RS10470	2145589..2146254	-	666	WP_001024095.1	SDR family oxidoreductase	-
I3K83_RS10475	2146406..2146726	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I3K83_RS10480	2146728..2147708	+	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
I3K83_RS10485	2147974..2149065	+	1092	WP_000495681.1	hypothetical protein	-
-	2149414..2149452	+	39	-	-	Antitoxin
I3K83_RS10490	2149507..2149611	-	105	WP_001802298.1	hypothetical protein	Toxin
I3K83_RS10495	2150291..2150449	+	159	WP_001792784.1	hypothetical protein	-
I3K83_RS10500	2151107..2151964	-	858	WP_000370930.1	Cof-type HAD-IIB family hydrolase	-
I3K83_RS10505	2152032..2152814	-	783	WP_000908180.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T182305 WP_001802298.1 NZ_CP065199:c2149611-2149507 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T182305 NZ_CP086391:4767988-4768515 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT182305 NZ_CP065199:2149414-2149452 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin