Detailed information of TA system TA182292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2145660..2145844
• Replicon: chromosome
• Accession: NZ_CP065194
• Organism: Staphylococcus aureus strain GDC6P096P

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: I3K80_RS10735
• Protein ID: WP_000482647.1
• Coordinates: 2145737..2145844 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2145660..2145720 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K80_RS10720	2141114..2141281	-	168	WP_001798790.1	hypothetical protein	-
I3K80_RS10725	2141512..2143245	-	1734	WP_000486511.1	ABC transporter ATP-binding protein/permease	-
I3K80_RS10730	2143270..2145033	-	1764	WP_001064818.1	ABC transporter ATP-binding protein/permease	-
-	2145660..2145720	+	61	-	-	Antitoxin
I3K80_RS10735	2145737..2145844	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
I3K80_RS10740	2145978..2146364	-	387	WP_000779355.1	flippase GtxA	-
I3K80_RS10745	2146631..2147773	+	1143	WP_001176859.1	glycerate kinase	-
I3K80_RS10750	2147833..2148492	+	660	WP_000831300.1	hypothetical protein	-
I3K80_RS10755	2148680..2149891	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
I3K80_RS10760	2150014..2150487	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T182292 WP_000482647.1 NZ_CP065194:c2145844-2145737 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T182292 NZ_CP086391:1919313-1919600 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT182292 NZ_CP065194:2145660-2145720 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin