Detailed information of TA system TA182290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1848796..1849059
• Replicon: chromosome
• Accession: NZ_CP065194
• Organism: Staphylococcus aureus strain GDC6P096P

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: I3K80_RS09195
• Protein ID: WP_001802298.1
• Coordinates: 1848955..1849059 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1848796..1848960 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K80_RS09175	1844981..1845646	-	666	WP_001024099.1	SDR family oxidoreductase	-
I3K80_RS09180	1845798..1846118	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I3K80_RS09185	1846120..1847100	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
I3K80_RS09190	1847366..1848457	+	1092	WP_000495673.1	hypothetical protein	-
-	1848796..1848960	+	165	-	-	Antitoxin
I3K80_RS09195	1848955..1849059	-	105	WP_001802298.1	hypothetical protein	Toxin
I3K80_RS09200	1849739..1849897	+	159	WP_001792784.1	hypothetical protein	-
I3K80_RS09205	1850333..1850425	+	93	WP_000220902.1	hypothetical protein	-
I3K80_RS09210	1850555..1851412	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
I3K80_RS09215	1851480..1852262	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
I3K80_RS09220	1852552..1853160	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T182290 WP_001802298.1 NZ_CP065194:c1849059-1848955 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T182290 NZ_CP086391:1447654-1447908 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT182290 NZ_CP065194:1848796-1848960 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin