Detailed information of TA system TA182285

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 721001..721250
• Replicon: chromosome
• Accession: NZ_CP065194
• Organism: Staphylococcus aureus strain GDC6P096P

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: I3K80_RS03675
• Protein ID: WP_000623369.1
• Coordinates: 721001..721108 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	721103..721250 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K80_RS03650	717675..718244	-	570	WP_000287265.1	competence protein ComK	-
I3K80_RS03655	718454..718672	+	219	WP_000876826.1	IDEAL domain-containing protein	-
I3K80_RS03660	718753..719739	-	987	WP_000668814.1	lipoate--protein ligase	-
I3K80_RS03665	719938..720114	+	177	WP_000214898.1	YkvS family protein	-
I3K80_RS03670	720129..720731	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
I3K80_RS03675	721001..721108	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	721103..721250	-	148	-	-	Antitoxin
I3K80_RS03680	721743..722027	+	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
I3K80_RS03685	722071..724035	+	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
I3K80_RS03690	724038..724358	+	321	WP_000668623.1	YxeA family protein	-
I3K80_RS03695	724355..724996	+	642	WP_000571192.1	ABC transporter ATP-binding protein	-
I3K80_RS03700	725084..725374	-	291	WP_001796515.1	hypothetical protein	-
I3K80_RS03705	725464..725652	+	189	WP_157958947.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
I3K80_RS03710	725741..726097	-	357	WP_000766009.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T182285 WP_000623369.1 NZ_CP065194:721001-721108 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T182285 NZ_CP086391:c266093-265629 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 148 bp

>AT182285 NZ_CP065194:c721250-721103 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTGCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin