Detailed information of TA system TA182282

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 4171238..4172589
• Replicon: chromosome
• Accession: NZ_CP065178
• Organism: Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: A0A086EBR9
• Locus tag: IG605_RS19170
• Protein ID: WP_039279924.1
• Coordinates: 4171549..4172589 (+)
• Length: 347 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: IG605_RS19165
• Protein ID: WP_193400345.1
• Coordinates: 4171238..4171552 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG605_RS19140 (IG605_019075)	4167059..4168093	+	1035	WP_193407437.1	putative FMN-dependent luciferase-like monooxygenase	-
IG605_RS19145 (IG605_019080)	4168090..4169223	+	1134	WP_193407438.1	alkylhydroperoxidase domain protein	-
IG605_RS19150 (IG605_019085)	4169280..4169792	-	513	WP_164671261.1	phenolic acid decarboxylase	-
IG605_RS19155 (IG605_019090)	4169892..4170764	+	873	WP_039550214.1	LysR family transcriptional regulator	-
IG605_RS19160 (IG605_019095)	4170927..4171253	+	327	WP_180784395.1	helix-turn-helix domain-containing protein	-
IG605_RS19165 (IG605_019100)	4171238..4171552	+	315	WP_193400345.1	HipA N-terminal domain-containing protein	Antitoxin
IG605_RS19170 (IG605_019105)	4171549..4172589	+	1041	WP_039279924.1	HipA domain-containing protein	Toxin
IG605_RS19175 (IG605_019110)	4172699..4173454	+	756	WP_193407439.1	thiol:disulfide interchange protein DsbG	-
IG605_RS19180 (IG605_019115)	4173488..4174393	-	906	WP_193407440.1	siderophore-interacting protein	-
IG605_RS19185 (IG605_019120)	4174660..4176012	-	1353	WP_193399014.1	glutathione-disulfide reductase	-
IG605_RS19190 (IG605_019125)	4176141..4176983	-	843	WP_102118774.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (57-307)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 347 a.a.
• Molecular weight: 39611.59 Da
• Isoelectric Point: 6.4479

>T182282 WP_039279924.1 NZ_CP065178:4171549-4172589 [Pectobacterium quasiaquaticum]
MTRCRILLTPLTHEEEIATGYSRKGLKHLAGKMHTSPDLRFTRQQFMHDLPQAQKGMSISGYQPKIQLVLEEQAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKTHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLMHLRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADLTKEAECVETTYRDSFMP
ADAIETTLRCYRHRLNLMSILDAERI

Nucleotide

• Length: 1041 bp

>T182282 NZ_CP086388:c38126-37605 [Escherichia coli]
GTGAGCAATACGACGATCGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCGCT
AAACGCATTTTTGACCAACCACTTAAAAAGACAGCATGAAGGAAAAATTCTTCGCGCTTATGTGCTTTGCACTAAAGAAG
AAATACCAAAGGTATTAGGTTATTACACTTTGTCAGGCAGCTGCTTTGAGAAAGAAACCTTACCTTCAAAGAGTCAGCAA
AAGAAAGTGCCTTATCGGCATGTCCCAAGTATCACTTTAGGCAGACTGGCTTTGGACAAATCTCTTCAAGGTCAGGGGCT
TGGCTCAATGCTTGTAACTCACGCAATGCGTGTTGTGTACAATGCATCTCTTGCGGTAGGCATTCATGGGCTTTTCGTTG
AGGCGTTGAACGATAAAGCCAGGGCGTTTTATAAAAGTTTGGGCTTTATCCAGCTGGTTGGTAACAACGATCGTTCTTTG
TTCTATCCAACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11875.70 Da
• Isoelectric Point: 9.8040

>AT182282 WP_193400345.1 NZ_CP065178:4171238-4171552 [Pectobacterium quasiaquaticum]
MRRQVKVYLYGVNIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSRTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA

Nucleotide

• Length: 315 bp

>AT182282 NZ_CP086388:c38403-38134 [Escherichia coli]
ATGTCCGCACTGAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACCCAGTTCATGGTTAGCAGTGCATCCGAACGTGCCGTGAAGGTGATAGAGCAACACCGTAGAC
TGGTTCTAAGTGAAGAGTCCTGGAATCTGGTTATGGATGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCCAATCGTCTGAAAAGCATGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A086EBR9