Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2682156..2682816 Replicon chromosome
Accession NZ_CP065178
Organism Pectobacterium quasiaquaticum strain A398-S21-F17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IG605_RS12455 Protein ID WP_193398912.1
Coordinates 2682463..2682816 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IG605_RS12450 Protein ID WP_010284412.1
Coordinates 2682156..2682458 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG605_RS12425 (IG605_012400) 2677268..2678704 - 1437 WP_193407319.1 glycoside hydrolase family 1 protein -
IG605_RS12430 (IG605_012405) 2678918..2679373 - 456 WP_193407320.1 helix-turn-helix domain-containing protein -
IG605_RS12435 (IG605_012410) 2679440..2680696 + 1257 WP_193407321.1 MFS transporter -
IG605_RS12440 (IG605_012415) 2680711..2681061 - 351 WP_193399971.1 metalloregulator ArsR/SmtB family transcription factor -
IG605_RS12445 (IG605_012420) 2681114..2682118 + 1005 WP_193399972.1 threonine/serine dehydratase -
IG605_RS12450 (IG605_012425) 2682156..2682458 - 303 WP_010284412.1 helix-turn-helix transcriptional regulator Antitoxin
IG605_RS12455 (IG605_012430) 2682463..2682816 - 354 WP_193398912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IG605_RS12460 (IG605_012435) 2683242..2684081 + 840 WP_193407322.1 glutathione-dependent disulfide-bond oxidoreductase -
IG605_RS12465 (IG605_012440) 2684200..2685171 - 972 WP_116227157.1 chemotaxis protein -
IG605_RS12470 2685587..2685807 + 221 Protein_2422 IS3 family transposase -
IG605_RS12475 (IG605_012445) 2686429..2687166 + 738 WP_193398914.1 LuxR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13472.49 Da        Isoelectric Point: 9.8932

>T182274 WP_193398912.1 NZ_CP065178:c2682816-2682463 [Pectobacterium quasiaquaticum]
VWKIETTDVFDSWFGTLNDRDRAYVLAALIVLREKGPMLSRPYADTVKGSQYSNMKELRIQSGGMPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMIPLADREFTKYLKKSEKRG

Download         Length: 354 bp

>T182274 NZ_CP086373:1559121-1559471 [Paenibacillus polymyxa]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGCCCTACCGTGATCGTAGCAGCCATCACAGCACAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTGGAGCAAATC
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTGGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAGATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11107.90 Da        Isoelectric Point: 6.2283

>AT182274 WP_010284412.1 NZ_CP065178:c2682458-2682156 [Pectobacterium quasiaquaticum]
MGRTLEQLLADEKPDVVVEAHAIAADMLLNIHLAELRERVQKTQVEMAQVLGLKQPTIAGMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYGFTL

Download         Length: 303 bp

>AT182274 NZ_CP086373:1558833-1559114 [Paenibacillus polymyxa]
TTGGCCAATTTGCAGAACACCAAAAGAATAATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGC
TATGGAGAATTCCAACCGCAGTGAATTTATCAGGCAGGCAATGAAGCTTTATGTAGGTGAACGTAAAAAACGTTACATTC
GTGAAGCTATGCAGCGTGGATACATGGAAATGGCTAAAATTAACCTGACCATGGCATCTGAAGCCTTTCACGCGGAGGAA
GATGCAAACAGCACCTTGGGCCGTACAGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References