Detailed information of TA system TA182260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 4061695..4062530
• Replicon: chromosome
• Accession: NZ_CP065177
• Organism: Pectobacterium quasiaquaticum strain A477-S1-J17

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: IG609_RS18620
• Protein ID: WP_193399197.1
• Coordinates: 4061695..4062180 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: IG609_RS18625
• Protein ID: WP_180785957.1
• Coordinates: 4062186..4062530 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG609_RS18600 (IG609_018585)	4057271..4058680	-	1410	WP_193399194.1	FtsX-like permease family protein	-
IG609_RS18605 (IG609_018590)	4058677..4059369	-	693	WP_193399195.1	ABC transporter ATP-binding protein	-
IG609_RS18610 (IG609_018595)	4059378..4059857	-	480	WP_039277140.1	hypothetical protein	-
IG609_RS18615 (IG609_018600)	4059870..4061615	-	1746	WP_193399196.1	alkaline phosphatase	-
IG609_RS18620 (IG609_018605)	4061695..4062180	-	486	WP_193399197.1	type II toxin-antitoxin system YhaV family toxin	Toxin
IG609_RS18625 (IG609_018610)	4062186..4062530	-	345	WP_180785957.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
IG609_RS18630 (IG609_018615)	4062724..4062879	-	156	WP_193399198.1	efflux RND transporter permease subunit	-
IG609_RS18635 (IG609_018620)	4062991..4063398	-	408	WP_226373213.1	hypothetical protein	-
IG609_RS18640 (IG609_018625)	4063388..4064089	-	702	WP_039277137.1	hypothetical protein	-
IG609_RS18645 (IG609_018630)	4064120..4064599	-	480	WP_039277134.1	Hcp family type VI secretion system effector	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4054259..4064599	10340

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-148)

Antitoxin

• PrlF antitoxin (15-113)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 18628.32 Da
• Isoelectric Point: 9.5852

>T182260 WP_193399197.1 NZ_CP065177:c4062180-4061695 [Pectobacterium quasiaquaticum]
MVDKRVINGWQLFTHPCFDAQFESLIVEVEQLRKKYPESYQKKQATKLLAAIVKVIRTEICGDPSQTKFRQGDTLGGGNK
HWFRAKFLGQYRLFFRYSERHKTIILAWVNDSDTKRAYGDQHDAYKVFSGMLASGNPPGDWEQLLAESHSEAMLTQMLVR
P

Nucleotide

• Length: 486 bp

>T182260 NZ_CP086370:211169-211507 [Massilia sp. HC52]
GTGACCGGCACCGCCTACGTCCCGGACGAAGGCGACATCGTCTGGATGAACTTCACCCCGCAAAGCGGCCACGAACAGGC
CGGCCGCCGCCCTGCCGTCGTCCTGTCGCCAAAATCCTACAATCTGCGCGCCGGCTTGCTGGTCTGCGTGCCGGTCAGTC
AAATCAAAGGCTATCCATTTGAAGTCGCCCTGACCGGCATGGGCGCAACCGGCGCCGCACTGGCGGACCAGGTAAAAAAC
GTGGACTGGCAGACCCGCAAGGCGGAACATAAAGGCAAGGCCAGCGCCGCCGAGATGGGCCAGATCCGCGCCAAAATCAA
AACCCTGCTGCGGCTATAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12845.46 Da
• Isoelectric Point: 4.4510

>AT182260 WP_180785957.1 NZ_CP065177:c4062530-4062186 [Pectobacterium quasiaquaticum]
MFDLKSADVLLRADSRLTARSQTTIPSSVRDAMNLQPGEYIHYSVLPGGQVLISRREEVIDDDPVIHHFLHFLAEDMQRH
PENIKPFDQSLMSRASVLTAGMDIDLDAPLTDDE

Nucleotide

• Length: 345 bp

>AT182260 NZ_CP086370:210930-211172 [Massilia sp. HC52]
ATGGCAAGGCAAGTACTCAAGAAGTGGGGCAACAGCACGGCGGTCCGGTTGCCCGCAGCGGTGATGGAAGCCGCCAATCT
GGCAGTCGACCAAGCCGTTGACGTGCGCGCTGAGCATGGGCGCGTCATTATCGAAGCGGCGGCGCCCATCTATCTGCTTG
ATGACCTGCTTGAAGGCATCACGCCGGAAAACCGCCACGGCGAGGTCGATACCGGCGCGCCGCAAGGCAAAGAGCTGCTG
TGA