Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 364225..364871 Replicon chromosome
Accession NZ_CP065167
Organism Klebsiella pneumoniae strain KPN114

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag I3U24_RS01685 Protein ID WP_016529833.1
Coordinates 364225..364572 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag I3U24_RS01690 Protein ID WP_004174017.1
Coordinates 364572..364871 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U24_RS01675 360151..361584 + 1434 WP_002920564.1 glycogen synthase GlgA -
I3U24_RS01680 361602..364049 + 2448 WP_002920561.1 glycogen phosphorylase -
I3U24_RS01685 364225..364572 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I3U24_RS01690 364572..364871 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
I3U24_RS01695 364934..366442 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
I3U24_RS01700 366647..366976 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
I3U24_RS01705 367027..367857 + 831 WP_032428425.1 rhomboid family intramembrane serine protease GlpG -
I3U24_RS01710 367907..368665 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T182204 WP_016529833.1 NZ_CP065167:364225-364572 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T182204 NZ_CP086340:2648564-2648671 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT182204 WP_004174017.1 NZ_CP065167:364572-364871 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT182204 NZ_CP086340:c2648517-2648451 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References