Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5049405..5050007 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag I2T83_RS24220 Protein ID WP_000897305.1
Coordinates 5049696..5050007 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I2T83_RS24215 Protein ID WP_000356395.1
Coordinates 5049405..5049695 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS24180 5045150..5045785 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
I2T83_RS24185 5045782..5046711 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
I2T83_RS24190 5046893..5047135 - 243 WP_021523315.1 hypothetical protein -
I2T83_RS24195 5047354..5047572 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
I2T83_RS24200 5048024..5048721 - 698 Protein_4732 IS1 family transposase -
I2T83_RS24205 5048750..5049046 - 297 WP_203135151.1 hypothetical protein -
I2T83_RS24210 5049108..5049320 - 213 WP_000197769.1 hypothetical protein -
I2T83_RS24215 5049405..5049695 - 291 WP_000356395.1 helix-turn-helix domain-containing protein Antitoxin
I2T83_RS24220 5049696..5050007 - 312 WP_000897305.1 hypothetical protein Toxin
I2T83_RS24225 5050236..5051144 + 909 WP_001306651.1 alpha/beta hydrolase -
I2T83_RS24230 5051313..5053127 - 1815 WP_020233236.1 hypothetical protein -
I2T83_RS24235 5053543..5054484 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
I2T83_RS24240 5054529..5054966 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T182100 WP_000897305.1 NZ_CP065136:c5050007-5049696 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T182100 NZ_CP086305:2506937-2507518 [Burkholderia ambifaria]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGACGGGCCGCTCCGAAAGCACGGCGGAGCACAGCTGGCGTCTCTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGACGTCGACACGACGAAACTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCGGACAAGAGCACGCACGAACGCGACGACCTGCTGACGCTGACGGCCGGGCTCGATCG
CGCGCTGCGCAACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGAATCGCCGGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTGGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGGCGGCGCTACACCGACGCGACGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGACGCGGACACGCAACGCCGGATCGA
CGCACGCGGCGACGGCACGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT182100 WP_000356395.1 NZ_CP065136:c5049695-5049405 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT182100 NZ_CP086305:2506270-2506827 [Burkholderia ambifaria]
ATGACGACCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTTGCCGCGCGTCTCGATTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCGAAC
AGCACGGCCCACATGCATCTCGTGTGCGACCTCACGCACCGTCTGCTCGCCTGTTCGCCATCGCGCGCCGCCGAGTTCTC
TCGGCCGCTGCCGATGTTGCTCGGTACCTCGCTGTGGCGCTATGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGATCGCGCGGGACCGCCGAGCGTCGAATTCACGACCGGCACCAATGCGTCGCGCGTCGTGCCG
ATCCGTGGCAGCACCTGCCGGTGGACGCGCATGACGCTGTCGGACGGCTCCGCCGCGCGGCTCGTCGAAACGCTGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7


Antitoxin

Source ID Structure

References