182078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2057882..2058384 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag I2T83_RS09800 Protein ID WP_000767829.1
Coordinates 2058130..2058384 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag I2T83_RS09795 Protein ID WP_001259255.1
Coordinates 2057882..2058133 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS09770 2053060..2054127 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
I2T83_RS09775 2054127..2055197 - 1071 WP_000108937.1 histidinol-phosphate transaminase -
I2T83_RS09780 2055194..2056498 - 1305 WP_021523144.1 histidinol dehydrogenase -
I2T83_RS09785 2056504..2057403 - 900 WP_021523143.1 ATP phosphoribosyltransferase -
I2T83_RS09790 2057549..2057599 - 51 WP_001364200.1 his operon leader peptide -
I2T83_RS09795 2057882..2058133 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
I2T83_RS09800 2058130..2058384 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
I2T83_RS09805 2058467..2059291 + 825 WP_000754758.1 SDR family oxidoreductase -
I2T83_RS09810 2059337..2060266 + 930 WP_023154044.1 LysR family transcriptional regulator -
I2T83_RS09815 2060481..2060543 + 63 WP_010723108.1 membrane protein YoeI -
I2T83_RS09820 2060533..2061891 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
I2T83_RS09825 2062070..2063128 + 1059 WP_000492324.1 transport protein YeeE -
I2T83_RS09830 2063142..2063369 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T182078 WP_000767829.1 NZ_CP065136:2058130-2058384 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T182078 NZ_CP086298:1939416-1939697 [Burkholderia ambifaria]
ATGACCTTTGAGCTTGCCTTTCTCGAACCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCATCCGCGACCAGTTCAA
ATCCCGACTCGCCGAGCGCCTCGAGAATCCCCGCATTGCGTCGGCCAAGCTGCATGGCCATCCGGATCGCTACAAGATCA
AGCTGCGCAGCGTCGGCTACCGACTCGTCTACGAAGTGCGCGATACGGAAGTGATCGTACTGGTTGTCGCAGTCGGTCGC
CGTGACCGCGATGCCGTCTATCTTGCCGCGATGAAGCGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT182078 WP_001259255.1 NZ_CP065136:2057882-2058133 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT182078 NZ_CP086298:1939178-1939426 [Burkholderia ambifaria]
ATGCCTCACACCATTCTGGCCAATGTTACGGCGAGCGTTTCGGAACTGAAGCGCAATCCGATGGGAACCGTCGCGGCGGG
CGAGGGCTTTCCGGTTGCGATTCTGAATCACAACGAGCCCGCGTTCTATTGCATCCCGGCGAAGACGTGGGAAGCGATGG
TCGAACGTCTCGAAGATATAGAAGACAACGCGCTTGCCAATACGCGTGCGAAGGACAAGGTCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References