182072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 735003..735696 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I2T83_RS03490 Protein ID WP_000415584.1
Coordinates 735003..735299 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I2T83_RS03495 Protein ID WP_000650107.1
Coordinates 735301..735696 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS03455 730091..730405 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
I2T83_RS03460 730436..731017 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
I2T83_RS03465 731336..731668 + 333 WP_023149630.1 DUF2645 family protein -
I2T83_RS03470 731714..733063 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
I2T83_RS03475 733060..733719 - 660 WP_001221493.1 two-component system response regulator QseB -
I2T83_RS03480 733871..734263 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I2T83_RS03485 734316..734798 + 483 WP_000183505.1 transcriptional regulator -
I2T83_RS03490 735003..735299 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I2T83_RS03495 735301..735696 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I2T83_RS03500 735829..737436 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
I2T83_RS03505 737574..739832 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T182072 WP_000415584.1 NZ_CP065136:735003-735299 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T182072 NZ_CP086298:58449-59360 [Burkholderia ambifaria]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTACGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGGGCCAGCTCGACACGCTCGGCGCGTCGCGA
CGCGTGCTCGCGTGGGATGCGCCCGGCTACGGCGTGTCGACTCCCGTGCACGGCGCGTCGCCGACCGCCGCCGATTACGC
GGCGTCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCG
CGGGCGGCTTGTGCCGCCTGAGGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCCGCGCG
CCCGCCGAAACGCGCGACACGCGCCGCGACGCGCGCCTCGCGATGCTCGACGAACTCGGTCCGGCCGGGCTCGCCGAGCA
GCGCAGCGGCAACATGCTGTCGGGTTTTGCGAGCGAAGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTATGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGCACG
GCTGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAGTT
GCAGGTGATTCCGCAGGCCGGTCATGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCGTCGCTGATCGACACGTTCTGTC
GTCAGTGCGACACGCAGCGAGGTAGGGCATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT182072 WP_000650107.1 NZ_CP065136:735301-735696 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT182072 NZ_CP086298:59357-60214 [Burkholderia ambifaria]
ATGAGCGAACCGCTGCAACAACCAGAATCCGACAGCACCAAGGCCGACGCCGGCTACGTGGTGCCGGGCCTCGAACGCGG
CCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCTGACAAGGATCGCAACTACAAG
CTGGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGCCTGCCCGTGATCGA
GAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGATGTGGTGTTCGTCGCAAAGGCAC
AGTGCCAGTCGCCGGTGTTCAGCGCGATTCGCGTGAATGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGTGCGCTGTATCCGGAAGGCACGCTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTGAGCAATTCGTCGTTCG
AGCGCGGTATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGAGGCATTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References