Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3115566..3116191 Replicon chromosome
Accession NZ_CP065135
Organism Halomonas venusta strain PBH

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IR195_RS14615 Protein ID WP_206047928.1
Coordinates 3115898..3116191 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IR195_RS14610 Protein ID WP_125750333.1
Coordinates 3115566..3115874 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR195_RS14585 3111189..3111962 + 774 WP_206047925.1 HD domain-containing protein -
IR195_RS14590 3112158..3112568 - 411 WP_197915462.1 PaaI family thioesterase -
IR195_RS14595 3112621..3113247 - 627 WP_206047926.1 LysE family translocator -
IR195_RS14600 3113386..3114810 - 1425 WP_206047927.1 sensor domain-containing diguanylate cyclase -
IR195_RS14605 3115092..3115427 - 336 WP_125750330.1 PhnA domain-containing protein -
IR195_RS14610 3115566..3115874 - 309 WP_125750333.1 HigA family addiction module antidote protein Antitoxin
IR195_RS14615 3115898..3116191 - 294 WP_206047928.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IR195_RS14620 3116293..3117906 - 1614 WP_206047929.1 ATP-binding cassette domain-containing protein -
IR195_RS14625 3118147..3119280 - 1134 WP_206047930.1 MFS transporter -
IR195_RS14630 3119425..3120327 + 903 WP_206047931.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-97)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11022.59 Da        Isoelectric Point: 6.7031

>T182070 WP_206047928.1 NZ_CP065135:c3116191-3115898 [Halomonas venusta]
MIVNFKDKAVEDLFNGEHTKAARKLCPLSLWKIASRKLDLLDSAQKLDELRVPPGNRLEALSGDRAGQHSICINGQYRLC
FRWTEAGPDEVELVDYH

Download         Length: 294 bp

>T182070 NZ_CP086296:172137-172436 [Burkholderia sp. B21-007]
ATGCCGATTGAGGCGCGTCTGGTGCGGCTGACGCCGCTGGCCGAGGCCGATCTCGAGGATATCTGGACCTACACCTTCGA
ACGCTGGTCGCTTGAGCAGGCCGAGCACTATGTGGGCGAGCTCGCCTCGGCGTTCGAGCGTCTCGCGCGGCGCGAGTGGA
GAGGGCGACCGAGTCGTGCGGGCAACGGCTATTGGCGCTACATGGTCGGTTCCCACGTGGTGTTCTATCGGGAAACGGCC
GAGAGCCTGGACGTGATTCGGGTATTGCATCAACGCATGGACGTGGACCGGCACCTGTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 12094.93 Da        Isoelectric Point: 6.6446

>AT182070 WP_125750333.1 NZ_CP065135:c3115874-3115566 [Halomonas venusta]
MIRVPTHREPTHPGEMLLEEFLQPMDITQRELAAAIHVPYQRINELVNKKRGVTPSTALRLARFFDVSADFWLNLQMRWD
LFKAEQLEHEDLSSIQHWQKMA

Download         Length: 309 bp

>AT182070 NZ_CP086296:171902-172147 [Burkholderia sp. B21-007]
ATGGCACGGAACACTTCAATCTCGCTGGGAGACCACCTGACGCAGTTTGTCGACACGCAGGTCGCGTCCGGTCGCTATGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGCTGCGCCTGCTCGAAACGCAGGAAACCGAGTTGCGGGCCCTGCAGGAGGCCT
TGAAGGCCGGCGAGGCCTCGGGCGAGCCGACTGCCTTTGACAGCCAGGCGTTCTTGGAGCGGATGCGGAAAAAGCATGCC
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References