Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 23786..24371 | Replicon | plasmid p5637 |
| Accession | NZ_CP065052 | ||
| Organism | Acinetobacter baumannii strain 2016GDAB1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N9CJF7 |
| Locus tag | IVB58_RS18495 | Protein ID | WP_000897307.1 |
| Coordinates | 24051..24371 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IVB58_RS18490 | Protein ID | WP_000369781.1 |
| Coordinates | 23786..24058 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IVB58_RS18465 (IVB58_18420) | 18811..19614 | + | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
| IVB58_RS18470 (IVB58_18425) | 19614..20450 | + | 837 | WP_000480968.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
| IVB58_RS18475 (IVB58_18430) | 20550..20688 | + | 139 | Protein_26 | helix-turn-helix domain-containing protein | - |
| IVB58_RS18480 (IVB58_18435) | 20878..21762 | - | 885 | WP_000155092.1 | Mph(E) family macrolide 2'-phosphotransferase | - |
| IVB58_RS18485 (IVB58_18440) | 21818..23293 | - | 1476 | WP_000052512.1 | ABC-F type ribosomal protection protein Msr(E) | - |
| IVB58_RS18490 (IVB58_18445) | 23786..24058 | - | 273 | WP_000369781.1 | NadS family protein | Antitoxin |
| IVB58_RS18495 (IVB58_18450) | 24051..24371 | - | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IVB58_RS18500 (IVB58_18455) | 24530..25171 | - | 642 | WP_004787586.1 | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein | - |
| IVB58_RS18505 (IVB58_18460) | 25237..26424 | + | 1188 | WP_004856455.1 | tetracycline efflux MFS transporter Tet(39) | - |
| IVB58_RS18510 (IVB58_18465) | 26667..26846 | - | 180 | Protein_33 | recombinase family protein | - |
| IVB58_RS18515 (IVB58_18470) | 26910..27614 | + | 705 | WP_005028420.1 | IS6 family transposase | - |
| IVB58_RS18520 (IVB58_18475) | 27668..27916 | - | 249 | Protein_35 | LysR family transcriptional regulator | - |
| IVB58_RS18525 (IVB58_18480) | 27944..29158 | - | 1215 | WP_000214122.1 | chloramphenicol/florfenicol efflux MFS transporter FloR | - |
| IVB58_RS18770 | 29157..29279 | + | 123 | WP_256442623.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | dfrA19 / ARR-3 / qacE / sul1 / aph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39) / floR / tet(Y) | - | 1..72156 | 72156 | |
| - | inside | IScluster/Tn | dfrA19 / ARR-3 / qacE / sul1 / aph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39) / floR / tet(Y) | - | 2092..38390 | 36298 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12187.95 Da Isoelectric Point: 7.1639
>T182058 WP_000897307.1 NZ_CP065052:c24371-24051 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG
Download Length: 321 bp
>T182058 NZ_CP086292:1834064-1834381 [Burkholderia ambifaria]
ATGCCATACAGTGCACCAACATTCAGTATCCGGACCACCGACGTCTTCGACGCGTGGTTTGCCGGCCTGCAGGATCGCGT
CGCGAAGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGGCCCGGCTATCGCGTCTACTACGTCAGGCGCGGAACGATATGGGTGATCCTGCTC
TGCGGCGGCGACAAGTCGACGCAACAGGGGGACATCCGCGCCGCGCACGCGATGCTCGCGCGGCTCGACCTGGAGTGA
ATGCCATACAGTGCACCAACATTCAGTATCCGGACCACCGACGTCTTCGACGCGTGGTTTGCCGGCCTGCAGGATCGCGT
CGCGAAGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGGCCCGGCTATCGCGTCTACTACGTCAGGCGCGGAACGATATGGGTGATCCTGCTC
TGCGGCGGCGACAAGTCGACGCAACAGGGGGACATCCGCGCCGCGCACGCGATGCTCGCGCGGCTCGACCTGGAGTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10149.61 Da Isoelectric Point: 8.6582
>AT182058 WP_000369781.1 NZ_CP065052:c24058-23786 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
Download Length: 273 bp
>AT182058 NZ_CP086292:1834385-1834684 [Burkholderia ambifaria]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGACTACTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAGGCGCACGCGTGA
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGACTACTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAGGCGCACGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|