Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4411397..4411899 Replicon chromosome
Accession NZ_CP065044
Organism Pectobacterium aroidearum strain L6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7W2E5L4
Locus tag I2D83_RS19650 Protein ID WP_039282578.1
Coordinates 4411645..4411899 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W2E625
Locus tag I2D83_RS19645 Protein ID WP_039324900.1
Coordinates 4411397..4411648 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2D83_RS19630 4407797..4408756 + 960 WP_012773138.1 ABC transporter permease -
I2D83_RS19635 4408749..4409615 + 867 WP_010285293.1 ABC transporter permease -
I2D83_RS19640 4409612..4411321 + 1710 WP_205947162.1 ABC transporter ATP-binding protein -
I2D83_RS19645 4411397..4411648 + 252 WP_039324900.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
I2D83_RS19650 4411645..4411899 + 255 WP_039282578.1 Txe/YoeB family addiction module toxin Toxin
I2D83_RS19655 4411959..4412813 - 855 WP_205947163.1 helix-turn-helix domain-containing protein -
I2D83_RS19660 4412838..4413677 - 840 WP_205947164.1 HTH-type transcriptional activator RhaS -
I2D83_RS19665 4414013..4415503 + 1491 WP_205947165.1 rhamnulokinase -
I2D83_RS19670 4415500..4416762 + 1263 WP_205947166.1 L-rhamnose isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.79 Da        Isoelectric Point: 8.0353

>T182044 WP_039282578.1 NZ_CP065044:4411645-4411899 [Pectobacterium aroidearum]
VKLIWSEEAWEDYLYWQDIDKRMVKKINELIKETRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T182044 NZ_CP086287:4037103-4037444 [Citrobacter freundii]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9367.64 Da        Isoelectric Point: 4.6119

>AT182044 WP_039324900.1 NZ_CP065044:4411397-4411648 [Pectobacterium aroidearum]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNSIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT182044 NZ_CP086287:4036765-4037082 [Citrobacter freundii]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E5L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E625

References