Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25754..26426 Replicon chromosome
Accession NZ_CP065044
Organism Pectobacterium aroidearum strain L6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I2D83_RS00115 Protein ID WP_180779426.1
Coordinates 26040..26426 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I2D83_RS00110 Protein ID WP_180779427.1
Coordinates 25754..26053 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2D83_RS00090 20989..21996 + 1008 WP_205947323.1 nucleoside hydrolase -
I2D83_RS00095 21996..22973 + 978 WP_012772765.1 ABC transporter permease -
I2D83_RS00100 22970..23878 + 909 WP_012772766.1 ABC transporter permease -
I2D83_RS00105 23918..25717 + 1800 WP_205947324.1 ABC transporter ATP-binding protein -
I2D83_RS00110 25754..26053 - 300 WP_180779427.1 XRE family transcriptional regulator Antitoxin
I2D83_RS00115 26040..26426 - 387 WP_180779426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I2D83_RS00120 26642..27139 + 498 WP_205947325.1 GNAT family N-acetyltransferase -
I2D83_RS00125 27339..27596 - 258 WP_012772768.1 DUF1471 domain-containing protein -
I2D83_RS00130 27769..28569 - 801 WP_205947326.1 aliphatic sulfonates ABC transporter ATP-binding protein -
I2D83_RS00135 28566..29360 - 795 WP_180779424.1 aliphatic sulfonate ABC transporter permease SsuC -
I2D83_RS00140 29371..30513 - 1143 WP_180779423.1 FMNH2-dependent alkanesulfonate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14834.84 Da        Isoelectric Point: 4.7331

>T182035 WP_180779426.1 NZ_CP065044:c26426-26040 [Pectobacterium aroidearum]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLGILEEDGPQLGRPQVDQIKGSQYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENEKLFYERMIKIADAEFTSHLISPEVKEDGDI

Download         Length: 387 bp

>T182035 NZ_CP086285:c4661165-4660881 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11082.10 Da        Isoelectric Point: 10.6442

>AT182035 WP_180779427.1 NZ_CP065044:c26053-25754 [Pectobacterium aroidearum]
MATFKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT182035 NZ_CP086285:c4661397-4661155 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References